摘要
胰岛素抵抗是2型糖尿病的主要病理机制之一,主要表现为肝脏、骨骼肌以及脂肪等胰岛素敏感的靶组织对葡萄糖的摄取和利用障碍。研究表明,葡萄糖转运体蛋白是胰岛素信号传导通路的重要靶蛋白,参与组织细胞对葡萄糖的利用。本文主要从中药及其复方通过多途径、多靶点促进葡萄糖转运体的易位及其基因表达而改善2型糖尿病胰岛素抵抗研究新进展进行综述,以期为2型糖尿病的防治提供新思路。
Insulin resistance is one of the main pathophysiological mechanism of type 2 diabetes mellitus,which mainly occurs in the liver,skeletal muscle,fat and other insulin sensitive target tissue for glucose uptake and utilization disorder. The research finds that the glucose transporter protein is the medium for the insulin signal transduction pathway to stimulate cells to glucose utilization. This paper reviews that the traditional Chinese medicine and its formulation through a variety of ways to promote glucose transporter protein translocation and（or） glucose transporter gene expression to improve the IR in type 2 diabetes mellitus.
作者
李斌
李鑫
范源
LI Bin;LI Xin;FAN Yuan(Schools of Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 550200,China;Hunan Provincial Key Laboratory of Diagnostics in Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410007,China)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2018年第6期863-866,共4页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
中药
2型糖尿病
胰岛素抵抗
葡萄糖转运体
Chinese Herbal
Type 2 Diabetes Mellitus
Insulin Resistance
Glucose transporter
