摘要
目的探讨良性阵发性位置性眩晕(BPPV)与甲状腺功能及自身抗体的相关性。方法收集2016年1~6月在温州医科大学附属第三医院耳鼻咽喉科收治的BPPV患者40例为实验组,选取40例无眩晕健康体检人员为对照组。两组均收集血管相关危险因素(高血压、糖尿病、冠心病等),并测定甲状腺功能5项、甲状腺过氧化物抗体(TPOAb)、甲状腺球蛋白抗体(TGAb),两组对比分析。结果实验组和对照组在既往血管相关危险因素(高血压、糖尿病、冠心病)差异无统计学意义(P>0.05);实验组甲状腺相关指标T3、T4、FT3、FT4与对照组比较差异无统计学意义(P>0.05)。实验组TSH与对照组比较差异有统计学意义;实验组甲状腺自身抗体总阳性率22.5%,对照组2.5%,差异有统计学意义。其中TPOAb阳性1例,两组比较差异无统计学意义,但TGAb阳性8例,与对照组比较差异有统计学意义,全部TGAb阳性的BPPV患者均为女性。结论 BPPV与甲状腺自身免疫可能存在一定相关性。女性BPPV患者应注意甲状腺相关指标检测。
OBJECTIVE To investigate the correlation of benign paroxysmal positional vertigo with thyroid function and autoantibodies. METHODS The total of 40 patients with BPPV and 40 age-and gender-matched control subjects were recruited in our hospital from January 2016 to June 2016. All risk factors such as the histories of vascular diseases and Thyroid function（T3, T4, FT3, FT4,TSH）, anti-thyroid peroxidase antibody（TPOAb）, antithyroid antibody（TGAb） were analyzed between 2 groups.RESULTS No significant difference existed in age,gender,histories of hypertension（P〈0.05）. No significant differences existed between T3, T4, FT3, FT4, TPOAb in patients with BPPV compared with controls（P〈0.05）.Compared with normal control group,the TSH in BPPV group was higher（χ2=-2.285, P〈0.05）. The value of TGAb was higher in patients with BPPV versus controls（χ~2=6.135,P〈0.05）, and all patients with positive TGAb were women.CONCLUSION There is a correlation between benign paroxysmal positinal vertigo and thyroid autoimmunity.In patients with BPPV, thyroid related indicators should be examined,especially for women.
作者
陈茹
洪丽丽
苏小青
周静
黄益灯
CHEN Ru;HONG Lili;SU Xiaoqing;ZHOU Jing;HUANG Yideng(Department of Otolaryngology, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325200, China;Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China)
出处
《中国耳鼻咽喉头颈外科》
CSCD
2018年第6期297-299,共3页
Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词
眩晕
甲状腺疾病
自身免疫
抗原抗体反应
良性阵发性位置性眩晕
Vertigo
Thyroid Diseases
Autoimmunity
Antigen-Antibody Reactions
benign paroxysmal positional vertigo
