摘要
目的比较和探讨外周血NEUT-X参数、超敏CRP(hs-CRP)及降钙素原(PCT)在儿童上呼吸道细菌感染诊断中的临床意义。方法以健康体检儿童(对照组,n=191)为对照,检测上呼吸道细菌感染患儿(上呼吸道细菌感染组,n=215)外周血NEUT-X参数、hs-CRP及PCT水平。结果儿童上呼吸道细菌感染组外周血NEUT-X参数为1 403.17±45.82,hs-CRP为32.4±1.8mg/L,PCT为0.61±0.07ng/ml,均高于对照组(1 325.61±32.53,3.5±0.4mg/L,0.20±0.05ng/ml),差异均有统计学意义(t=2.587,7.539,3.986,均P<0.05)。儿童上呼吸道细菌感染诊断时,血清PCT的ROC曲线下面积最大为0.849,其次为外周血NEUT-X参数0.811及hs-CRP 0.792。外周血NEUT-X参数,hs-CRP及PCT三者联合检测其敏感度为0.938,特异度为0.885,均显著高于三者单独检测,其诊断效能最高。结论外周血NEUT-X参数,hs-CRP及PCT升高均可单独作为儿童上呼吸道细菌感染的指标,三者联合检测可作为儿童上呼吸道细菌感染诊断的重要指标。
Objective To detect the clinical significance of peripheral blood NEUT-X parameters, hypersensitive CRP （hs- CRP） and procalcitonin （PCT） in the diagnosis of bacterial upper respiratory tract infection in children. Methods The levels of peripheral blood NEUT-X parameters, hs-CRP and PCT in children with bacterial upper respiratory tract infection （bacte- rial upper respiratory tract infection group, n= 215） and in healthy children （control group, n = 191） were measured. Results The peripheral blood NEUT-X parameters of the bacterial infection group in children＇s upper respiratory tract infection were 1 403.17±45.82,hs-CRP was 32. 4521.8 mg/L and PCT was 0.61±0.07 ng/ml,and they were all higher than the peripheral blood parameters of the control group. The parametrs of NEUT-X were 1 325.61± 32.53,hs-CRP was 3.5 ± 0.4 mg/L, PCT was 0.20± 0.05 ng/ml, and the difference were statistically significant （t = 2. 587,7. 539,3. 986, P〈 0.05） . During the diagnosis of the upper respiratory tract bacterial infection in children,the area under the ROC cuve of the serum PCT was 0. 849, follow by the parameters of the peripheral blood NEUT-X were 0. 811 and hs-CRP was 0. 792. The sensi- tivity of the peripheral blood NEUT-X, hs-CRP and PCT combined monitoring was 0. 938, and the specificity was 0. 885. The sensitivity and specificity were all higher than those of the three separate test. It had the highest diagnostic efficiency. Conclusion Peripheral blood NEUT-X parameters,hs-CRP and PCT can be used alone as a marker of bacterial upper re- spiratory tract infection in children. And even, the panel of these three parameters can be used as a more important diagnosis indicator of bacterial upper respiratory tract infection in children.
作者
颜宇飞
陈燕
李灵筠
吴亲芳
秦琴
YAN Yu-fei;CHEN Yan;LI Ling-jun;WU Qin-fang;QIN Qin(la. Department of Clinical Laborator;1b. Department of Paediatrics , Shanghai Kongjiang Hospital, Shanghai 200093, China;2. Department of Experimental Diagnosis, the First Affiliated Hospital of the Navy Military Medical University ,Shanghai 200433 ,China)
出处
《现代检验医学杂志》
CAS
2018年第3期123-125,共3页
Journal of Modern Laboratory Medicine
