期刊文献+

肝素结合蛋白分泌机制及其早期诊断脓毒症研究进展 被引量:15

下载PDF
导出
摘要 肝素结合蛋白(HBP)是存在于中性粒细胞嗜苯胺蓝颗粒和分泌颗粒中的一种蛋白分子。由Shafer等发现,因其带正电荷,具有灭菌活性,相对分子量为37×103而被命名为CAP37。后来Gabay等将其命名为天青杀素。1991年,Flodgaard等发现其具有极强的结合肝素能力,将其命名为肝素结合蛋白,二者结合后HBP的活性明显受抑制。
作者 许程 徐元宏
出处 《国际检验医学杂志》 CAS 2015年第1期100-101,共2页 International Journal of Laboratory Medicine
  • 相关文献

参考文献32

  • 1Tapper H, Karlsson A, Morgelin M, et al. Secretion of heparin- binding protein from human neutrophils is determined by its lo- calization in azurophilic granules and secretory vesicles[J]. Blood, 2002,99(5) : 1785-1793. 被引量:1
  • 2Shafer W ML, Spitznagel J. Cationic antimicrobial proteins isola- ted from human neutrophil granulocytes in the presence of diiso- propyl fluorophosphate[J]. Infect Immun, 1984,45 (1) : 29-35. 被引量:1
  • 3Gabay J, Scott R, Campanelli D, et al. Antibiotic proteins of hu- man polymorphonuclear leukocytes [J]. Clin Res, 1989, 37 (2) : A563. 被引量:1
  • 4Flodgaard H, Stergaard E, Bayne S, et al. Covalent structure of two novel neutrophile leucocyte - derived proteins of porcine and human origin[J]. Eur J Bio, 1991,197(2) : 535-547. 被引量:1
  • 5Mccabe D,Cukierman T, Gabay JE. Basic residues in azurocidin/ HBP contribute to both heparin binding and antimicrobial activity [J]. J Biol Chem,2002,277(30) : 27477-27488. 被引量:1
  • 6Linder A, Akesson P, Brink M, et al. Heparin-binding protein.. A diagnostic marker of acute bacterial meningitis[J]. Crit Care Med, 2011,39(4) :812-817. 被引量:1
  • 7Kjolvmark C,Akesson P,linder a. elevated urine levels of heparin- binding protein in children with urinary tract infection[J]. Pediat- ric Nephrology,2012,27(8) :1301-1308. 被引量:1
  • 8Holub M,Beran O. Should heparin-binding protein levels be rou- tinely monitored in patients with severe sepsis and septic shock [J]. Critical Care, 2012,16(3) : 1-2. 被引量:1
  • 9Linder A, Arnold R, Zindovic M, et al. Heparin-binding protein improves prediction of severe sepsis in the emergency department [J]. Critical Care,2013,17(4) :3-4. 被引量:1
  • 10Chew MS, Linder A, Santen S, et al. Increased plasma levels of heparin-binding protein in patients with shock:a prospective,co- hort study[J]. Inflamm Res,2012,61(4) :375-379. 被引量:1

二级参考文献38

  • 1任晓旭,宋国维.第3代小儿死亡危险评分和小儿危重病例评分的应用[J].实用儿科临床杂志,2006,21(6):382-384. 被引量:76
  • 2Shafer WM, Martin LE, Spitznagel JK. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate[ J]. Infect Immun, 1984, 45 ( 1 ) : 29 - 35. 被引量:1
  • 3Pohl J, Pereira HA, Martin NM, et al. Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase[ J]. FEBS Lett, 1990, 272 (1,2) : 200 - 204. 被引量:1
  • 4Tapper H, Karlsson A, Mt~rgelin M, et al. Secretion of heparin- binding protein from human neutrophils is determined by its localiza-tion in azurophilic granules and secretory vesicles [ J ]. Blood, 2002, 99(5) : 1785 -1793. 被引量:1
  • 5Herwald H, Cramer H, Mfirgelin M, et al. M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage [ J ]. Cell, 2004, 116 ( 3 ) : 367 - 379.. 被引量:1
  • 6Nilsson M, Sqbrensen OE , MSrgelin M, et al. Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators [ J ]. Thromb Haemost, 2006, 95 (6) : 982 -990. 被引量:1
  • 7Gennaro AD, Kenne E, Wan M, et al. Leukotriene tM-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin)[J] FASEB J, 2009, 23(6): 1750-1757. 被引量:1
  • 8Linder A, Johansson L, Thulin P, et al. Erysipelas caused by GAS activates the contact system and induces the release of HBP [ J ]. J Invest Dermatol, 2010, 130(5) : 1365 - 1372. 被引量:1
  • 9McCabe D, Cukierman T, Gabay JE. Basic residues in azurocidin/ HBP contribute to both heparin binding and antimicrobial activity [J]. J Biol Chem, 2002, 277(30) : 27477 -27488. 被引量:1
  • 10Rasmussen PB, Bjorn S, Hastrup S, et al. Characterization of recombinant human HBP CAP37 azurocidin a pleiotropic mediator of inflammation-enhancing LPS-induced cytokine release from monocytes[J]. FEBS Lett, 1996, 390( 1 ) : 109 - 112. 被引量:1

共引文献30

同被引文献116

  • 1无.脓毒症的定义、诊断标准、中医证候诊断要点及说明(草案)[J].中华急诊医学杂志,2007,16(8):797-798. 被引量:266
  • 2邢豫宾,戴路明,赵芝焕,李志伟,李超.血清降钙素原和常用炎症指标结合SOFA评分对脓毒症早期诊断和预后价值的评价[J].中国危重病急救医学,2008,20(1):23-28. 被引量:123
  • 3Pfifflin A, Schleicher E. Inflammation markers in point- of-care testing (POCT) [J]. Anal Bioanal Chem, 2009, 393(5) : 1473-1480. 被引量:1
  • 4Linder A, Soehnlein O, Akesson P. Roles of heparin-bind- ing protein in bacterial infections [J]. J Innate Immun, 2010,2 (5) : 431-438. 被引量:1
  • 5Soehnlein O. Direct and alternative antimicrobial mecha- nisms of neutrophil-derived granule proteins [J]. J Mol Med (Berl) ,2009,87(12) :1157-1164. 被引量:1
  • 6Chew MS, Linder A, Santen S, et al. Increased plasma lev- els of heparin-binding protein in patients with shock: a prospective,cohort study[J]. Inflamm Res, 2012,61 (4) : 375-379. 被引量:1
  • 7Linder A, Akesson P, Inghammar M, et al. Elevated plas-ma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock[J]. Critical Care,2012,16(3): R90. 被引量:1
  • 8Linder A,Christensson B, Herwald H, et al. Heparin-binding protein:an early marker of circulatory failure in sepsis[J]. Clin Infect Dis, 2009,49 (7) : 1044-1050. 被引量:1
  • 9Kjelvmark C, Pghlman LI, Akesson P, et al. Heparin-binding protein:a diagnostic biomarker of urinary tract infection in a- dults[J]. Clin Infect Dis, 2014,1 (1) : 1-4. 被引量:1
  • 10Kaukonen KM, Linko R, Herwald H, et al. Heparin binding protein (HBP) in critically ill patients with influenza A (H1N1) infection[J]. Clin Microbiol Infect, 2013, 19 (12) : 1122-1128. 被引量:1

引证文献15

二级引证文献133

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部