摘要
目的：探讨 D-二聚体在脓毒症病情评估中的价值。方法选取48例脓毒症患儿，根据病情分为脓毒症组（26例）、严重脓毒症组（17例）、脓毒症死亡组（5例），每例患儿入院后第1、3天取血，进行血常规、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）及 D-二聚体检测。对比三组 PLT、PT、APTT、D-二聚体水平。结果第1天脓毒症死亡组 D-二聚体较严重脓毒症组升高（t ＝－6．465，P ＜0．05）、较脓毒症组明显升高（t ＝－8．621，P ＜0．01），第3天严重脓毒症组 D-二聚体较脓毒症组升高（t ＝－15．815，P ＜0．05），脓毒症死亡组较其余两组 D-二聚体明显升高（t ＝－8．629、－6．521，均 P ＜0．01）。结论通过监测脓毒症患儿凝血功能，其中 D-二聚体水平监测可早期识别病情严重的脓毒症，及早治疗，降低病死率。
Objective To investigate the value of D -dimer in evaluation on the severity of sepsis.Methods 48 children with sepsis were selected.According to the disease condition,they were divided into sepsis group（26 cases）, severe sepsis group （17 cases）,sepsis death group（5 cases）.1 and 3 days after admission,the blood samples were collected.The routine blood test,prothrombin time（PT）,activated partial thromboplastin time （APTT）,and D -dimer were tested.PLT,PT,APTT,D -dimer were compared among 3 groups.Results At the first day,the D -dimer level of the sepsis death group increased more than the severe sepsis group（t =-6.465,P 〈0.05）,which was significantly higher compared with the sepsis group（t =-8.621,P 〈0.01）.At the third day,the D -dimmer level of the severe sepsis group increased compared with the sepsis group （t =-15.815,P 〈0.05）,the D -dimer level of the sepsis death group significantly increased than in the other two groups（t =-8.629,6.521,all P 〈0.01）.Conclusion By monitoring coagulation in children with sepsis,D -dimer level monitoring can be a serious condition early recognition of sepsis,early treatment and reduce mortality.
出处
《中国基层医药》
CAS
2016年第23期3542-3544,共3页
Chinese Journal of Primary Medicine and Pharmacy
