摘要
目的探讨步长脑心通胶囊联合普罗布考治疗动脉粥样硬化性脑梗死对血流变学、血脂水平的影响。方法选取2015年10月—2017年2月我院收治的164例动脉粥样硬化性脑梗死患者为研究对象,随机分为治疗组和对照组,各82例。2组均给予常规治疗,对照组采用普罗布考治疗,治疗组在对照组的基础上加用步长脑心通胶囊治疗,2组均连续治疗6个月。比较2组治疗前后神经功能缺损状况、IMT、斑块面积、血流变学及血脂水平等;统计2组临床疗效;记录治疗中2组不良反应发生情况。结果治疗后2组NHISS评分与IMT均较治疗前显著下降,斑块面积较治疗前显著缩小,且治疗组NHISS评分、IMT均低于对照组,斑块面积小于对照组(P<0.01);治疗后治疗组总有效率为86.59%,显著高于对照组的70.73%(P<0.05);治疗后2组高/低切全血黏度、纤维蛋白原与治疗组红细胞压积均较治疗前显著下降(P<0.05或P<0.01),且治疗组上述指标水平均显著低于对照组(P<0.05或P<0.01);治疗后2组血清TG、TC及LDL-C水平均较治疗前显著下降,且治疗组低于对照组(P<0.01);治疗后2组血清HDL-C水平均较治疗前显著升高,且治疗组高于对照组(P<0.05或P<0.01);治疗中2组不良反应总发生率无显著差异(P>0.05)。结论步长脑心通胶囊联合普罗布考治疗动脉粥样硬化性脑梗死可有效改善患者血流变学,调节其血脂水平恢复正常,有效抑制动脉粥样硬化进展,临床疗效优于单用西药治疗。
Objective To explore the effect of Buchang Naoxintong capsule combined with probucol on the blood rheology and blood lipid level in atherosclerotic cerebral infarction patients. Methods 164 patients with atherosclerotic cerebral infarction admitted in our hospital from October 2015 to February 2017 were randomly divided into treatment group and control group,with 82 cases in each group. 2 groups were given conventional treatment. The control group was treated with probucol,and the treatment group was treated with Buchang Naoxintong capsule on the basis of the control group. 2 groups were treated for 6 months continuously. The neurological deficit,IMT,plaque area,blood rheology and blood lipid level were compared between 2 groups before and after treatment. The clinical efficacy and the occurrence of adverse reactions in 2 groups were recorded. Results The NHISS score and IMT of 2 groups after treatment were significantly lower than before treatment,and the plaque area significantly reduced comparing with before treatment,and the NHISS score and IMT of the treatment group were lower than control group,the plaque area of the treatment group was less than that of control group（ P〈0. 01）. The total effective rate of the treatment group was 86. 59%,which was significantly higher than that of the control group（ 70. 73%）（ P〈0. 05）.After treatment,the high/low cut whole blood viscosity,fibrinogen and hematocrit of 2 groups decreased significantly than before treatment（ P〈0. 05 or P〈0. 01）,and treatment group was significantly lower than control group（ P〈0. 05 or P〈0. 01）. After treatment,the serum TG,TC and LDL-C levels of 2 groups significantly decreased,and treatment group was lower than control group（ P〈0. 01）. After treatment,the serum HDL-C level of 2 groups were significantly higher than before treatment,and treatment group was higher than control group（ P〈0. 01）. The incidences of adverse reactions of 2 groups had no significant difference（ P〉0. 05）. Conclusion Buc
作者
闫双勇
张海英
YAN Shuangyong;ZHANG Haiying(Rehabilitation Department, Third People＇s Hospital, Shanxi Province, Linfen 041000, China)
出处
《光明中医》
2018年第10期1369-1372,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
关键词
中风
动脉粥样硬化
脑梗死
步长脑心通胶囊
血流变
血脂
Apoplexy
Atherosclerosis
Cerebral infarction
Buchang Naoxintong capsule
Blood rheology
Blood lipid
