摘要
真核生物DNA复制需要精确的调控,复制起始顺利开启至关重要,其中复制解旋酶的组装是复制起始的核心。作为解旋酶的核心组件,微小染色体维持蛋白(minichromosome maintenance proteins,Mcms)在真核细胞DNA复制的起始阶段扮演着重要的角色。目前,对Mcm2-7复合物的功能研究已开展较多,其在复制起始中的作用已有较为全面的解释。近些年研究发现,Mcm10也在DNA复制的起始调控中起重要作用。该文对近些年Mcm10在真核细胞复制起始中的功能研究进行综述,以期对相关领域的研究者有所帮助。
DNA replication of the eukaryotic requires precise and rigorous regulation, and it is really important for the initial success of replication initiation, and the assembly of the helicase is the core of the replication initiation. Minichromosome maintenance proteins（Mcms） that act as core components of the helicase and play a major role in the initiation of DNA replication. So far, there have been many studies on Mcm2-7 complex, and there is a comprehensive explanation for its function in the replication initiation. Subsequently, some studies have discovered that Mcm10 is also involved in control of DNA replication origin, but its precise function is not clear. This article gives a brief review about the function of Mcm10 in replication initiation in recent years.
作者
付凌玲
赵啸宇
徐进
Fu Lingling;Zhao Xiaoyu;Xu Jin(Department of Preventive Medicine, Medical School of Ningbo University, Ningbo 315211, China)
出处
《中国细胞生物学学报》
CAS
CSCD
2018年第5期788-794,共7页
Chinese Journal of Cell Biology
基金
浙江省公益技术应用研究项目(批准号:2017C33151)
宁波市自然科学基金(批准号:2015A610275)
浙江省大学生科技创新活动计划(批准号:2017R405068)资助的课题~~
