摘要
微囊技术可以提高益生菌在加工和贮存过程中的稳定性,并且可以实现益生菌在肠道内的定位和缓慢释放。然而由聚合物为囊材制备的微囊,若不做进一步修饰或处理,大多存在骨架疏松、硬度小等缺点,难以保证益生菌通过胃液后的存活率。近年来许多研究表明微囊包衣技术能够改善以上缺点,可以显著提高益生菌微囊对益生菌在模拟胃肠液中的保护效果,其中包衣技术与包衣材料是影响包衣效果的主要因素。本文主要综述了常用益生菌微囊包衣技术的基本原理及优缺点,并对常用包衣材料的结构、性质和应用等进行了总结,最后对益生菌微囊包衣技术的应用进行了展望。
Microencapsulation technology can improve the stability of probiotics during production and storage, which contributes to setting and slow release of probiotics in the intestinal tract. However, there are some disadvantages of unprocessed microcapsule such as loose skeleton, low hardness, further causing low probiotic survival rate. Recently, studies show that coating technology can improve the above shortcomings and significantly protect the probiotics in simulated gastrointestinal fluid. Coating process and materials are the main effect factors. Finally, the basic principle, characters and future directions of probiotic microcapsule coating technology, as well as the structure, properties and application of coating materials are discussed deeply in this paper.
作者
纪瑞
邵雷
王健
陈代杰
JI Rui;SHAO Lei;WANG Jian;CHEN Daijie(National Pharmaceutical Engineering Research Center, China State Institute of Pharmaceutical Industry, Shanghai 201203;State Key Lab. of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203;School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2018年第7期893-900,共8页
Chinese Journal of Pharmaceuticals
基金
国家自然基金项目(81373310
81573329
81773616)
上海市自然基金项目(16ZR1435400)
上海市优秀技术带头人计划(17XD1423200)
关键词
益生菌
微囊包衣
壳聚糖
层层自组装
乳清蛋白
probiotics
microcapsule coating
chitosan
layer by layer assembly
whey protein
