摘要
艾滋病病毒（HIV）耐药是目前艾滋病防治的主要障碍之一,随着药物的更新换代和治疗方案的改进,全球耐药毒株发生和流行的形势发生了很大改变,高收入国家和中低收入国家有较大的差异。本文介绍了目前全球获得性耐药和治疗前耐药流行的状况,分析了药物及治疗方案改进对耐药的影响,提出了预防和控制耐药的主要措施建议。
Objective HIV drug resistance is the major obstacle of AIDS prevention and control worldwide.As the upgrading of antiretroviral agents and the improvement of therapy regimens,the epidemic and trend of HIV-1 drug resistance strains have changed dramatically,Great difference exists between high income countries and low and middle income countries.In this paper,the epidemic of acquired drug resistance and pre-treatment drug resistance was introduced,the upgrading of drugs and therapy regimens on the emergence of drug resistance was analyzed,and finally,the response actions for prevention and control of drug resistance was proposed.
作者
李敬云
LI Jingyun(Institute of Microbiology and Epidemiology , Academy of Military Medical Science, Beijing 100071 , China)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2018年第6期635-638,642,共5页
Chinese Journal of Aids & STD
基金
病原微生物生物安全国家重点实验室自主研究课题(SKLPBS1512)~~
关键词
艾滋病病毒
耐药
抗病毒治疗
耐药监测
Human immunodeficiency virus
Drug resistance
Antiretroviral drugs
Drug resistance surveillance
