摘要
目的观察Ommaya囊置入联合放化疗治疗囊性野生型肺腺癌脑转移患者的临床疗效。方法通过对山东省肿瘤医院神经外科2016年至2017年收治的48例囊性野生型肺腺癌脑转移患者,采用Ommaya囊置入联合放化疗治疗,并对患者的治疗疗效、影像结果进行回顾性分析。结果 48例患者治疗前均有不同程度颅内压增高症状,包括头痛(39例),呕吐(27例),视物模糊(8例)等。局灶性体征包括肢体活动障碍(27例),癫痫发作(12例),视野缺损(10例),失语(8例)等。治疗后临床症状及体征好转,生活能力提高者36例,有效率75%。影像学好转者(病灶缩小50%)36例,有效率75%,进展者4例,死亡3例。结论Ommaya囊置入联合放化疗治疗囊性野生型肺腺癌脑转移瘤是一种有效并且安全的方法。
Objective To observe the clinical efficacy of Ommaya sac implantation combined with radiation and chemotherapy for treatment of cystic brain metastases from lung adenocarcinoma.Methods Clinical efficacy and imaging results of 48 patients with cystic brain metastases from lung adenocarcinoma were analyzed retrospectively using the treatment of Ommaya sac implantation combined with radiation and chemotherapy. Results Various degrees of high intracranial pressure were observed in48 patients before treatment,which caused headache in 39 patients,vomit in 27 and blurred vision in 8.Focal nervous damages were observed including physical impairment in 27 patients,epileptic seizure in12,defect of visual field in 10 and aphasia in 8. Improvement of clinical symptoms and activity of daily living were noted in 36 patients,imaging re-check indicated focus shrink 50% in 36 patients,enjoying an effective rate of 75%. Progressive disease was noted in 4 patients and deaths was noted in 3.Conclusion Treatment of cystic lung adenocarcinoma with brain metastases through Ommaya sac implantation combined with radiation therapy and chemotherapy is effective and safe.
作者
孟祥继
徐军
周士振
王勇
朱玉方
陶荣杰
MENG Xiang- ji;XU Jun;ZHOU Shi-zhen(Shandong Cancer Hospital, Jinan 250117, China)
出处
《临床神经外科杂志》
CAS
2018年第3期184-186,共3页
Journal of Clinical Neurosurgery
关键词
Ommaya囊置入术
放化疗
野生型肺腺癌
囊性转移瘤
Ommaya sac
radiotherapy and chemotherapy
wild-type adenocarcinoma of lung
metastatic brain tumors
