摘要
探讨腺苷对实验性股动脉狭窄远段微细血管的影响。选用Wistar大鼠随机分为实验组(股动脉结扎)与对照组(股动脉下仅穿线,不结扎),根据检测方法的不同各分为光学微血管造影组、双光子荧光显微镜组和Adora2a受体免疫组织化学组,分别于尾静脉持续注射腺苷。腺苷可减少实验组股动脉狭窄远段的血流量及微细血管数量,且实验组腺苷Adora2a受体表达的阳性率明显低于对照组。腺苷在股动脉实验性狭窄模型中有缩血管作用,该作用与腺苷Adora2a受体含量的改变有关。
Objective： To explore the effect of adenosine on the distal microvessels of experimental femoral artery stenosis. Methods： Wistar rats were randomly divided into six groups： experimental groups （femoral artery ligated） and control groups （threading without ligation under the femoral artery）. According to the detection methods, each group was divided into optical microangiograph group, 2-photon group and Adora2a receptor immunohistochemical group. And all of them were injected with adenosine in the tail vein. Results： Adenosine could reduce the blood flow and the number of microvessels in the distal segment of the femoral artery in the experimental group. The expression of adenosine Adora2a receptor in the experimental group was significantly lower than that in the control group. Conclusion： Adenosine has vasoconstrietive effect in the experimental stenosis model of femoral artery, and this is related to the change of the content of adenosine Adora2 a receptor.
作者
王佳惠
史树堂
鲍红图
郑立双
郗昕
Wang Jiahui;Shi Shutang;Bao Hongtu;Zheng Lishuang;Xi Xin(Department of Morphology, School of Medicine;Experimental Center, Affiliated Hospital, Hebei University, Baoding 071000, China)
出处
《解剖学杂志》
CAS
CSCD
2018年第3期253-255,共3页
Chinese Journal of Anatomy
基金
河北大学博士基金(hbdx20161106)
