摘要
目的:研究伊曲康唑对中重度脂溢性皮炎(seborrheic dermatitis,SD)的有效性。方法:纳入中重度SD患者49例,分为伊曲康唑组(25例)与对照组(24例)。伊曲康唑组给予曲安奈德益康唑乳膏2次/天(4周),同时于第1周口服伊曲康唑200 mg/d,1月后每个月的前2天,脉冲性口服伊曲康唑200 mg/d共3个月,在第2周、第1、2、3月观察疗效。对照组仅给予曲安奈德益康唑乳膏2次/天(4周)。结果:两组在第2周、第1、2、3月的临床有效率分别为92.0%、80.0%、84.0%及92.0%,对照组对应为83.3%、79.2%、62.5%、54.2%。脂溢性皮炎面积严重程度指数(Seborrheic dermatitis area and severity index,SDASI)在治疗初期两组无统计学意义(P>0.05),治疗结束后两组SDASI相比较,差异具有统计学意义(P<0.05);两组瘙痒及烧灼评分比较,差异均有统计学意义(P<0.01)。伊曲康唑组复发率明显低于对照组(P<0.01),患者耐受性良好。结论:伊曲康唑可有效控制中重度SD的发作及维持症状缓解,降低复发率,耐受性良好。
Objective To study the efficacy of oral itraconazole in the treatment of moderate to severe seborrheic dermatitis.Methods A total of 49 patients with moderate-severe SD were enrolled into itraconazole group（ n = 25） and control group（ n= 24）. In the itraconazole group,triamcinolone acetonide cream was given twice a day（ 4 weeks）,while itraconazole 200 mg/d was given in the first week. One month later,patients were pulsed with oral administration of itraconazole 200 mg/d on the first two days of each month for 3 months. The efficacy was started to be observed on the second week followed by 1 st,2 nd,and 3 rd month. The control group was given triamcinolone acetonide cream twice daily（ 4 weeks）. Results The clinical effective rates of the two groups were 92.0%,80.0%,84.0% and 92.0% in the second week,1st,2nd and 3rd month,respectively. The control group was 83.3%,79.2%,62.5%,54.2%. There was no significant difference between the two groups（ P〉 0. 05） in the early stage of treatment as indicated by seborrheic dermatitis area and severity index（ SDASI）,and the difference was statistically significant（ P〈0.05） after the treatment. There was a significant difference in itching and cauterization scores between the two groups（ P〈 0. 01）. Itraconazole group recurrence rate was significantly lower than the control group（ P〈0.01）. All patients were well tolerated. Conclusion Itraconazole can effectively control the onset of moderate to severe SD and maintain the relief of symptoms,reduce the recurrence rate and be well tolerated.
作者
杨焦丽
王雪
刘玉峰
YSNG Jiao-ii;WANG Xue;LIU Yu-feng(Department of Dermatology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000,Chin)
出处
《湖北医药学院学报》
CAS
2017年第6期532-534,539,共4页
Journal of Hubei University of Medicine
关键词
伊曲康唑
脂溢性皮炎
治疗
hraconazole
Seborrheic Dermatitis
Treatment
