摘要
目的探讨6~17岁正常体重少年儿童体质指数对高血压前期和高血压的非线性效应。方法对苏州地区2015年中小学学生健康体检资料进行统计分析。根据2010年中国学生体质与健康调研报告中分年龄和性别的结果,对体质指数进行标准化,并计算体质指数得分。采用限制性立方样条模型,对体质指数与高血压前期和高血压的非线性效应进行分析,其发生风险采用立方样条-logistic回归进行估计,根据年龄、性别和身高进行分层分析。结果体质指数得分对高血压前期和高血压的效应均为非线性(P值均<0.01)。年龄、性别和身高分层分析进一步证实存在这种非线性效应。结论正常体重少年儿童中,体质指数对高血压前期和高血压的效应为非线性。在控制超重和肥胖者血压的同时,仍需关注正常体重少年儿童人群的血压控制。
Objective Obesity is a well-established risk factor of elevated blood pressure;however,the relationships between normal weight status and the risk of hypertension and pre-hypertension are not clear.This study aimed to describe the blood pressure effects of adiposity in non-overweight children.Methods 588,097 non-overweight children aged 6-17 years were included from National Surveys on Students＇Constitution and Health.Body mass index（BMI）z-score was calculated based on the age-and gender-standardised national references.Pre-hypertension and hypertension were assessed according to the recent international blood pressure references.The dose-response relationships between BMI z-score and risk of pre-hypertension and hypertension were assessed using a restricted cubic spline function.Results A non-linear relationship was found between age-and gender-standardized body mass index（BMI）z-score and pre-hypertension and hypertension,respectively.The above-mentioned associations were consistent in subgroup analysis by age,gender and height.Conclusion Non-linear relationships of BMI z-scores with pre-hypertension and hypertension were found in non-overweight children.Interventions to control blood pressure are also important in non-overweight children.
作者
朱莉
Zhu Li(Kunshan Center for Disease Control and Prevention, Kunshan , Jiangsu 215300)
出处
《江苏预防医学》
CAS
2018年第3期262-264,310,共4页
Jiangsu Journal of Preventive Medicine
