摘要
目的:探讨CEA、VEGF、P53、LDH在鉴别良性、恶性胸腔积液中的诊断价值。方法:选择2016年8月-2017年2月收治的54例胸腔积液患者,其中恶性胸腔积液25例作为观察组,良性胸腔积液29例作为对照组,检测两组CEA、VEGF、P53、LDH表达水平,比较其差异。结果:恶性胸腔积液组CEA、VEGF、P53水平明显高于良性胸腔积液组(P<0.05),LDH水平在两组中差异无统计学意义(P>0.05)。结论:CEA、VEGF、P53蛋白在恶性胸腔积液中表达水平较高,LDH在良性及恶性胸腔积液差异不明显,联合检测CEA、VEGF、P53较为合适。
Objective：To investigate the diagnostic value of CEA,VEGF,P53 protein and LDH in differentiating benign and malignant pleural effusion.Methods：54 patients with pleural effusion from August 2016 to May 2017,25 cases with malignant pleural effusion as observation group,29 cases with benign pleural effusion as control group.The expression levels of CEA,VEGF,P53 and LDH were detected in two groups,and compare their differences.Results：The levels of CEA,VEGF and P53 in malignant pleural effusion group were significantly higher than those in benign pleural effusion group（P〈0.05）,there was no significant difference in LDH level between the two groups（P〈0.05）.Conclusion：The expression levels of CEA,VEGF and P53 protein were higher in malignant pleural effusion,there was no significant difference of LDH between benign and malignant pleural effusion,combined detection of CEA,VEGF,P53 protein and LDH has important clinical significance in the detection of pleural effusion.
作者
唐冠军
张艳丽
TANG Guanjun,ZHANG Yanli(Department of Respiratory,the People＇s Hospital of Xushui District,Baoding City,Hebei Province,07100)
出处
《医学理论与实践》
2018年第9期1262-1263,1273,共3页
The Journal of Medical Theory and Practice
基金
河北省保定市科技计划项目(17ZF080)
关键词
胸腔积液
良性
恶性
Pleural effusion
Benign,Malignant
