期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人附睾蛋白4在肺癌中的研究进展 被引量：6

Advances of Human Epididymis Protein 4 in Lung Cancer
下载PDF
导出
摘要 人附睾蛋白4(human epididymis 4,HE4)属于乳清酸性4-二硫化中心(WFDC)蛋白家族,具有胰蛋白酶抑制剂的特性。在肺癌患者血清中及恶性胸腔积患者胸水中呈高表达,现有临床数据显示它与肺癌的诊断及预后有一定的相关性,因此可能成为临床上肺癌的诊断及预后评估的新指标。 Human epididymis 4（HE4） belongs to whey acidic 4-disulfide center protein family. It has the characteristics of inhibiting trypsin and high expression in the serum or malignant pleural effusion of patients with lung cancer. Clinical data showed that it has certain relevance to the diagnosis and prognosis of lung cancer. HE4 may be a new indicator of clinical diagnosis and prognosis evaluation.
作者 马晴 王倩 钟殿胜
机构地区 天津医科大学总医院肿瘤科
出处 《中国肺癌杂志》 CAS CSCD 北大核心 2015年第3期184-186,共3页 Chinese Journal of Lung Cancer
关键词 人附睾蛋白4 肺肿瘤 进展 HE4 Lung neoplasms Progress
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Israeli O, Goldring-Aviram A, Rienstein S, et al. In silico chromosomal clustering of genes displaying altered expression patterns in ovarian cancer. Cancer Genet Cytogenet, 2005,160(1): 35-42. 被引量：1
  • 2Bouchard D, Morisset D, Bourbonnais Y, et al. Protein with whey-acidicprotein motifs and cancer. Lancet Oncol, 2006, 7(2): 167-174. 被引量：1
  • 3Bingle L, Singleton V, Bingle CD. The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. Oncogene, 2002, 21(17): 2768-2773. 被引量：1
  • 4Kirchhoff C, Habben I, Ivell R, et al. A major human epididymis-specific eDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. Biol Reprod, 1991,45(2): 350-357. 被引量：1
  • 5Hough CD, Sherman-Baust CA, Pizer ES, et al. Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Cancer Res, 2000, 60(22): 6281-6287. 被引量：1
  • 6Galgano MT, Hampton GM, Frierson Jr HF. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol, 2006, 19(6): 847-853. 被引量：1
  • 7Ross DT, Scherf V, Eisen MB, et al. Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet, 2000, 24(3): 227-235. 被引量：1
  • 8Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with pelvic mass. Gynecol Oncol, 2008,108(2): 402-408. 被引量：1
  • 9Holcomb K, Vucetic Z, Miller MC, et al. Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women. Am J Obstet Gynecol, 2011, 205(4): 358·366. 被引量：1
  • 10Karisen MA, Sandhu N, Hogdall C, et al. Evaluation ofHE4, CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer in patients with a pelvic mass. Gynecol Oncol, 2012,127(2): 379·383. 被引量：1

二级参考文献11

  • 1Galgano MT, Hampton GM, Frierson HJ. Comprehensive analysis of HE4 expression in normal and malignant human tissues[J].Mod Pathol,2006,19(6):847-853. 被引量：1
  • 2Molina R, Escudero JM, Auge JM, et al. HE4 a novel tumour mark- er for ovarian cancer: comparison with CA 125 and ROMA algo- rithm in patients with gynaecological diseases[J]. Tumour Biol,2011, 32(6):1087-1095. 被引量：1
  • 3Li J, Dowdy S, Tipton T, et al. HE4 as a biomarker for ovarian and endometrial cancer management[J]. Expert Rev Mol Diagn,2009,9 (6):555-566. 被引量：1
  • 4Tokuishi K, Yamashita S, Ohbo K, et al. Splice variant HE4-V3 ex- pression is associated with favorable prognosis in pulmonary adeno- caroinoma[J]. Tumour Biol,2012,33(1):103-109. 被引量：1
  • 5Kirchhoff C, Habben I, Ivell R, et al. A major human epididymis- specific eDNA encodes a protein with sequence homology to extra- cellular proteinase inhibitors[J]. Biol Reprod,1991,45(2):350-357. 被引量：1
  • 6lwabuchi H,Sakamoto M,Sakunaga H, et al. Genetic analysis of be- nign, low-grade, and high-grade ovarian tumors[J]. Cancer Res, 1995,55 (24):6172-6180. 被引量：1
  • 7Bouchard D, Morisset D, Bourbonnais Y, et al. Proteins with whey- acidic-protein motifs and cancer[J]. Lancet Oncol,2006,7(2):167- 174. 被引量：1
  • 8Bingle L, Cross SS, High AS, et al. WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung[J]. Respir Res, 2006,7:61. 被引量：1
  • 9Yamashita S,Tokuishi K,Moroga T, et al. Serum level of HE4 is closely associated with pulmonary.adenoearcinoma progression[J]. Tumour Biol,2012,33(6):2365-2370. 被引量：1
  • 10Iwahori K, Suzuki H, Kishi Y, et al. Serum HE4 as a diagnostic and prognostic marker for lung cancer[J] Tumour Biol,2012,33(4):1141- 114. 被引量：1

共引文献17

同被引文献38

引证文献6

二级引证文献13

中国肺癌杂志
2015年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部