摘要
目的:人类乳头瘤病毒(HPV)是女性发生宫颈癌的必要病因,也与男性阴茎癌、口咽癌、肛门癌等密切相关,但是目前对男性HPV的研究较少。本文研究配偶宫颈HPV感染男性外生殖器HPV感染状况,为临床制定HPV相关性疾病的防治措施提供科学依据。方法:收集2016年8~12月因配偶宫颈HPV感染阳性,南京医科大学附属妇产医院泌尿男科门诊就诊男性的相关资料。尼龙棉签拭子在阴茎头、冠状沟、包皮内板、阴茎体等处取样,运用凯普生物HPV分型检测试剂盒,采用PCR和膜杂交的方法,检测不同型别HPV感染情况。结果:去除不合格病例,共纳入139例患者信息。139例配偶宫颈HPV感染男性外生殖器HPV感染率为83.5%。HPV感染类型以6,16,39,18,58,52型为主,分别占43.2%(60/139)、19.4%(27/139)、10.1%(14/139)、9.4%(13/139)、9.4%(13/139)、9.4%(13/139)。在配偶宫颈HPV感染阳性的男性中,包皮过长比率高达75.5%,但包皮正常和包皮过长男性HPV感染率没有显著差异(P>0.05)。结论:配偶宫颈HPV感染阳性的男性是HPV感染的高危人群,有必要对此类人群进行筛查和治疗,以降低男女双方的HPV感染。
Objective ： Human papilloma virus （HPV） is a necessary cause of cervical cancer and is also closely related to pe- nile cancer, oropharyngeal cancer, and anal cancer in males. However, few studies are reported on male HPV. This study aimed to in- vestigate HPV infection of the external genitalia in men whose female partners have cervical HPV infection. Methods ： We collected the relevant data on the male outpatients whose partners had cervical HPV infection in our Department of Urology and Andrology from August to December 2016. We obtained samples with nylon swabs from the glans penis, corona, inner layer of the prepuce and penile body and detected different types of HPV infection using the Hybribio HPV typing kit, PCR and membrane hybridization. Results ： Valid data were collected from 140 males, which showed 83.5% of HPV infection of the external genitalia, including 60 cases of HPV6 （43.2%）, 27 cases of HPV16 （19.4%）, 14 cases of HPV39 （10. 1%）, 13 cases of HPV18 （9.4%）, 13 cases of HPV58 （9.4%） , and 13 cases of HPV52 （9.4%）. Redundant prepuce was found in 75.5% of the males, but there was no statistically sig- nificant difference in the incidence rate of HPV infection between the normal and redundant prepuce groups （P 〉 0. 05 ）. Conclu- sion ： Men who have the female partners with positive cervical HPV are at high risk of HPV infection and therefore need to be screenedand treated so as to reduce HPV infection in both sexes.
作者
潘连军
马洁桦
张峰磊
潘锋
赵丹
张兴源
PAN Lian-jun;MA Jie-hua;ZHANG Feng-lei;PAN Feng;ZHAO Dan;ZHANG Xing-yuan(Department of Urology and Andrology, Obstetrics and Gynecology Hospital of Nanfing Medical University / Nanfing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210004, China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2018年第6期516-519,共4页
National Journal of Andrology
基金
国家自然科学基金(81501239
81771572)
南京市医学科技发展项目(YKK14129)
南京市科技发展计划项目(201715051)
十三五南京市卫生青年人才培养工程(QRX17158)~~
关键词
人乳头瘤病毒
配偶
包皮过长
human papillomavirus
sex partner
redundant prepuce
