摘要
环状RNA是一类共价闭合环状非编码RNA,一般较为保守且稳定,广泛存在于各种生物体内。近年来,环状RNA在肿瘤治疗中的作用成为了一个研究热点,其中包括乳腺癌相关性环状RNA。研究显示,环状RNA在乳腺癌患者的血清及肿瘤组织中异常表达,且在不同分子分型的乳腺癌组织中表达具有特异性。异常表达的环状RNA与多种肿瘤相关基因都有密切的联系,它可通过结合微RNA或其他生物分子抑制后者的功能,直接或间接影响乳腺癌相关基因的表达,从而一方面影响乳腺癌细胞的增殖、侵袭与凋亡,另一方面影响乳腺癌患者对化疗药物的不良反应及耐药性。本文从环状RNA的生物学特征、功能以及近年来其在乳腺癌发生、发展及化疗药物耐药等方面的研究进展进行综述。
Circular RNAs （circRNAs） are a class of non-coding RNAs with covalently closed continuous loops. Owing to its specific molecular structure, circRNA is conserved and stable in vivo. Recently, the circRNAs have received extensive attention in the treatment of cancers including breast cancer. Notably, the recent evidence has demonstrated that circRNAs are aberrantly expressed in plasma and tumor tissues of breast cancer patients, and the expressions of those circRNAs in different subtypes of breast cancer were also heterogeneous. The abnormally expressed circRNAs are able to regulate the expression of cancer-related genes by binding their targeting microRNAs and other biomolecules to inhibit their functions. Moreover, the circRNAs are also considered as important players in the proliferation, invasion and apoptosis of breast cancer cells, as well as the treatment toxicities and drug-resistance. This paper reviews the biological characteristics and functional roles of cancer-related circRNAs, especially the current research on their association with occurrence, progression and drug-resistance of breast cancer.
作者
罗丽花
徐亮
曹亚丽
LUO Lihua;XU Liang;CAO Yali(Medical Department, Graduate School of Nanchang University, Nanchang 330006, Jiangxi Province, China;Department of Prevention and Cure Center of Breast Disease, The Third Hospital of Nanchang, Nanchang 330009, Jiangxi Province, China)
出处
《肿瘤》
CAS
CSCD
北大核心
2018年第6期623-630,共8页
Tumor
基金
江西省青年科学基金资助项目(编号:20171BAB215045)~~
关键词
乳腺肿瘤
RNA
未翻译
抗药性
肿瘤
环状RNA
Breast neoplasms
RNA
untranslated
Drug resistance
neoplasm
Circular RNA
