摘要
目的研究阿司匹林联合氯吡格雷对冠心病心绞痛患者血清血清高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平的影响,为临床诊治提供参考。方法选取我院于2016年11月至2017年11月收治的80例冠心病心绞痛患者患者,按照随机数表法平均分成两组。其中对照组采用阿司匹林治疗;观察组患者在对照组基础上联合氯吡格雷治疗,两组患者均进行30 d的治疗。对比两组患者治疗后临床疗效,血清脂质水平,hs-CRP、TNF-α及IL-6水平。结果治疗后,对照组患者总有效率77.5%,观察组总有效率85.0%,差异有统计学意义(P<0.05)。治疗后,两组患者TC、TG及LDL-C等血脂水平均较治疗前明显改善,且观察组优于对照组,差异均有统计学意义(P<0.05);且治疗后,两组患者血清hs-CRP、TNF-α及IL-6均较治疗前明显改善,且观察组优于对照组,差异均有统计学意义(P<0.05)。结论阿司匹林联合氯吡格雷治疗冠心病心绞痛,可显著提高患者临床疗效,改善患者TC、TG及LDL-C等血清脂质指标及hs-CRP、TNF-α及IL-6水平,值得在临床上推广。
Objective To study the protein reaction of aspirin combined with clopidogrel on coronary heart disease angina pectoris serum serum high-sensitivity C-（high-sensitivity C-reactive protein,hs-CRP）,tumor necrosis factor alpha（tumor necrosis factor-TNF-alpha,alpha）and interleukin-6（interleukin-6,IL-6）level,provide reference for clinical diagnosis and treatment. Methods In our hospital from November 2016 to November 2017 treated 80 cases of patients with angina pectoris were randomly divided into two groups. The control group was treated with aspirin;the observation group was treated with clopidogrel on the basis of the control group,and the two groups were treated with 30 D. The clinical efficacy,serum lipid levels,hs-CRP,TNF-alpha and IL-6 levels were compared between the two groups after treatment. Results after treatment,the total effective rate of the control group was 77.5%,and the total effective rate of the observation group was85%,the difference was statistically significant（P〈0.05）. After treatment,blood lipid levels of two groups were TC,TG and LDL-C were significantly improved after treatment,and the observation group than the control group,the differences were statistically significant（P〈0.05）;and after treatment,two groups of patients with serum hs-CRP,TNF-alpha and IL-6 were significantly improved after treatment,and the observation group than the control group. The differences were statistically significant（P〈0.05）. Conclusion Aspirin combined with clopidogrel in the treatment of coronary heart disease angina pectoris can significantly improve the clinical efficacy of patients,improve the serum lipid indexes such as TC,TG and LDL-C,and the levels of hs-CRP,TNF-alpha and IL-6 in patients with coronary heart disease,which is worthy of clinical promotion.
作者
尹叶全
YIN Ye-quan.(Medical Outpatient Pharmacy, Group of Fifth Hospital, Pharma-ceutical Corporation East Hubei, Huangshi, Hubei Province 435005, Chin)
出处
《解剖学研究》
CAS
2018年第3期178-181,共4页
Anatomy Research
