摘要
目的:探讨参麦注射液联合抗血小板药物对非ST段抬高ACS患者斑块性质、炎症反应的影响。方法;选择在本院接受治疗的非ST段抬高ACS患者142例,随机分为对照组、参麦注射液组各71例。对照组在常规治疗基础上加入抗血小板药物,参麦注射液在常规治疗基础上加入参麦注射液联合抗血小板药物。对比治疗前、治疗1周后两组血清中斑块性质相关指标、炎症因子含量的差异。结果:治疗前,两组血清中代谢指标、脂质指标、细胞黏附分子、炎症因子含量的差异无统计学意义。治疗1周后,参麦注射液组血清代谢指标中Hcy、UA的含量较对照组低;血清中脂质指标ox-LDL、Lp-PLA2的含量较对照组低;血清中黏附分子sVCAM-1、sICAM-1的含量较对照组低;血清中炎症因子IL-1β、IL-6、IL-17、IL-23的含量较对照组低。结论:非ST段抬高ACS患者接受参麦注射液辅助治疗,可进一步稳定斑块并抑制全身炎症反应。
Objective:To investigate the effect of Shenmai injection combined with antiplatelet drugs on the plaque property and inflammatory response in patients with non-ST-segment elevation ACS.Methods:A total of 142 patients with non-ST-segment elevation ACS who were treated in the hospital between June 2015 and September 2017 were divided into control group(n=71)and Shenmai injection group(n=71)by random number table method.Control group received antiplatelet drugs based on routine treatment,and Shenmai injection group received Shenmai injection combined with antiplatelet drugs on the basis of routine treatment.The differences in serum contents of plaque property-related indexes and inflammatory factors were compared between the two groups before and after treatment.Results:Before treatment,there was no significant difference in serum contents of metabolism indexes,lipid indexes,cell adhesion molecules and inflammatory factors between the two groups.After 1 week of treatment,serum metabolism indexes Hcy and UA contents of Shenmai injection group were lower than those of control group;serum lipid indexes ox-LDL and Lp-PLA2 contents were lower than those of control group;serum adhesion molecules sVCAM-1 and sICAM-1 contents were lower than those of control group;serum inflammatory factors IL-1β,IL-6,IL-17 and IL-23 contents were lower than those of control group.Conclusion:Adjuvant Shenmai injection therapy can further stabilize the plaques and inhibit the systemic inflammatory response in patients with non-ST-segment elevation ACS.
出处
《海南医学院学报》
CAS
2018年第1期12-15,共4页
Journal of Hainan Medical University
基金
湖北省基金重点项目(2014CFA061)~~
关键词
非ST段抬高ACS
参麦注射液
斑块性质
炎症反应
Non-ST-segment elevation ACS
Shenmai injection
Plaque property
Inflammatory response
