摘要
铁离子是大多数细菌生存所必需的营养物质,但是过多的铁离子通过芬顿反应产生的活性氧(reactive oxygen species,ROS)对细菌造成损伤。因此,细菌必须严格控制体内铁离子浓度。铁摄取调节子(ferric uptake regulator,Fur)是细菌铁离子代谢中最重要的调节子。Fur通过抑制或者激活基因的转录,来调节与铁摄取、利用和储存相关的基因,维持胞内铁离子浓度动态平衡。此外,Fur还参与细菌的氧化应激、抗酸能力、毒力和能量代谢等多种生物过程的调节。本文对Fur参与的生物过程及调节机制进行介绍,以期为进一步研究其他细菌Fur的调节机制,以及Fur在细菌应对环境变化中所起作用提供参考。
Iron is an essential nutrient for most bacteria to survive,but excessive iron damages the bacteria through the Fenton reaction to produce reactive oxygen species（ ROS）. Thus,bacteria must strictly control the concentration of iron in vivo. Ferric uptake regulator（ Fur） is the most important regulator of iron metabolism in bacteria. Fur regulates the genes involved in iron uptake,utilization and storage by repressing or activating gene transcription and balancing intracellular iron concentration. In addition,Fur is also involved in the regulation of various biological processes such as bacterial oxidative stress,acid resistance,virulence,energy metabolism and so on. In this review,we mainly discuss the biological processes regulated by Fur and its mechanism. It will provide a reference for further mechanistic studies on Fur and its role in the bacterial response to environmental changes.
作者
刘珈均
程安春
刘马峰
LIU Jia-Jun;CHENG An-Chun;LIU Ma-Feng(Institute of Preventive Veterinary Medicine, College of Veterinary Medicin;Research Center of Avian Disease, College of Veterinary Medicin;Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2018年第6期595-603,共9页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金项目(No.31572521)
四川省国际科技合作与交流研究计划(No.16GH0030)资助~~
