摘要
目的对老年人单独及联合接种流感疫苗、23价肺炎球菌多糖疫苗（PPV23）进行安全性评价，提高老年人对接种流感疫苗和PPV23的安全性认识。方法2014年10月—2015年9月对符合接种条件≥60岁的老年人单独及联合接种流感疫苗、PPV23，观察接种后1个月内局部反应和全身反应发生情况。结果（1）所有观察对象、单独接种流感组、单独接种国产PPV23组、单独接种进口PPV23组、联合接种组Ⅰ（流感与国产PPV23联合接种）、联合接种组Ⅱ（流感与进口PPV23联合接种）预防接种反应发生率分别为10.13%、5.35%、11.63%、9.52%、17.24%和12.63%，均以局部反应、注射部位疼痛、轻度反应为主。反应均在7 d内出现，且主要发生在接种后30 min～1 d时间内（82.61%）；反应发生后均在7 d内恢复，绝大多数在1 d内恢复（84.78%）。（2）结果显示：联合接种组反应发生率相对单独接种组反应发生率高；单独接种疫苗组反应发生率：国产PPV23组高于进口PPV23组高于流感组，但差异无统计学意义（P〉0.05）；使用国产PPV23的联合接种组反应发生率高于使用进口PPV23的联合接种组，但差异无统计学意义（P〉0.05）。（3）不同人口学特征对比发现：女性、年龄≥70岁、患慢性病者单独及联合接种流感疫苗、PPV23反应发生率高于男性、60～69岁、未患慢性病者，但差异无统计学意义（P〉0.05）。结论不同性别、不同年龄的老年人无论是否患慢性疾病单独及联合接种流感疫苗、PPV23均是安全的、可耐受的，无论是国产PPV23还是进口PPV23均有良好的安全性。
Objective To evaluate the safety of influenza vaccine and 23-valent pneumococcal polysaccharide vaccine （PPV23） immunized alone or in combination in elderly people and to raise the awareness of vaccine safety among the elderly.MethodsFrom October 2014 to September 2015, 454 elderly people who were over 60 years old and immunized with influenza vaccine and PPV23 alone or in combination were recruited in this study and divided into five groups. Local and systemic reactions occurred within one month after vaccination were recorded.Results（1） Incidences of adverse reactions among all subjects and people vaccinated with influenza vaccine alone, domestic PPV23 alone, imported PPV23 alone, domestic PPV23 combined with influenza vaccine and imported PPV23 combined with influenza vaccine were 10.13%, 5.35%, 11.63 %, 9.52%, 17.24% and 12.63%, respectively. Local reaction, injection site pain and mild reaction were the common reactions to vaccination. All reactions occurred within seven days and most of them occurred within 30 minutes to one day after vaccination （82.61%）. All subjects recovered within seven days and most of them recovered within one day （84.78%）. （2） Compared with the people immunized with domestic or imported PPV23 or influenza vaccine alone, those immunized in combination had higher incidences of reactions to vaccination. Among the three single vaccination groups, domestic PPV23 group had the highest incidence of reactions, followed by imported PPV23 and influenza vaccine groups, but no significant difference was found among them （P〉0.05）. The incidence of responses to influenza vaccine combined with domestic PPV23 was higher than that to influenza vaccine combined with imported PPV23, but no significant difference was found between them （P〉0.05）. （3） In each group, women, people aged ≥70 years or with chronic diseases had a higher incidence of responses to vaccination than men, people aged 60 to 69 years or without chronic diseases, respectively （P〉0.05）.Concl
作者
何奔
向泽林
沈国初
杜哲群
许荣全
He Ben;Xiang Zelin;Shen Guochu;Du Zhequn;Xu Rongquan(Department of Immunization, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2018年第4期293-299,共7页
Chinese Journal of Microbiology and Immunology
基金
嘉兴市科技计划项目（2015AY23049）
关键词
老年人
流感疫苗
23价肺炎球菌多糖疫苗
联合接种
接种反应
The elderly
Influenza vaccine
23-valent pneumococcal polysaccharide vaccine
Combined vaccination
Vaccination reaction
