摘要
目的:探讨培美曲塞联合顺铂(PP)化疗方案对原发性晚期非小细胞肺腺癌患者中医证候的影响。方法:选取2015年1月至2017年1月新乡市中心医院肿瘤内科收治的经病理学检查明确确诊的晚期原发性非小细胞肺腺癌患者112例,进行PP化疗方案治疗,于化疗前8 d和化疗后第8天、16天分别观察患者的中医证型、舌象以及脉象。结果:化疗后第8天脾虚痰湿证患者(12.50%)明显少于化疗前8 d脾虚痰湿证患者(40.08%),差异有统计学意义(P<0.05);化疗后第8天气阴两虚证(27.68%)和气滞血瘀证(25.00%)患者明显多于化疗前8 d气阴两虚证(9.82%)和气滞血瘀证(7.14%)患者(P<0.05);化疗后8 d淡红舌(25.89%)、腻舌(11.61%)患者明显少于化疗前第8天淡红舌(36.61%)、腻舌(25.00%)患者(P<0.05);化疗后8 d红舌(33.93%)、紫暗舌(19.64%)、光剥苔(44.64%)患者明显多于化疗前第8天红舌(22.32%)、紫暗舌(5.36%)、光剥苔(21.43%)患者;化疗后8 d细脉(28.57%)、滑脉(9.82%)患者患者明显少于化疗前第8天细脉(37.50%)、滑脉(25.89%)患者患者,差异有统计学意义(P<0.05);化疗后8 d细数脉(22.32%)、弦脉(25.00%)患者明显多于化疗前第8天细数脉(9.82%)、弦脉(7.14%)患者,差异有统计学意义(P<0.05)。结论:原发性晚期非小细胞肺腺癌患者行PP方案前后中医证候变化有规律可循,化疗后气阴两虚证、气滞血瘀证,可在化疗前增加相应中医药干预治疗。
Objective： To investigate the effect of pemetrexed combined with cisplatin（ PP） chemotherapy on TCM syndrome of patients with advanced non-small cell lung adenocarcinoma. Methods： A total of 112 patients with advanced primary non-small cell lung adenocarcinoma who were confirmed by pathology in our hospital from January 2015 to January 2017 were treated with PP chemotherapy. The TCM syndromes,tongue images and pulse conditions were observed 8 days before chemotherapy and 8 and 16 days after chemotherapy respectively. Results： The number of patients with spleen deficiency and phlegm dampness syndrome（ 12. 50%） on the 8 th day after chemotherapy was significantly smaller than those with spleen deficiency and phlegm dampness syndrome（ 40. 08%） on the 8 th day before chemotherapy（ P 〈 0. 05）; On the 8 th day after chemotherapy,the number of patients with qi and yin deficiency（ 27. 68 %） and stagnation of qi and blood stasis syndrome（ 25. 00%） was significantly larger than those with qi and yin deficiency（ 9. 82%） and stagnation of qi and blood stasis syndrome（ 7. 14%） before chemotherapy（ P 0. 05）. The number of patients with pale red tongue（ 25. 89%） and greasy tongue（ 11. 61%） on the 8 th day after chemotherapy was significantly smaller than those with pale red tongue（ 36. 61%） and greasy tongue（ 25. 00%） on the 8 th day before chemotherapy（ P 〈 0. 05）. The number of patients with red tongue（ 33. 93%）,dark purple tongue（ 19. 64%）,and light peeled tongue（ 44. 64%） was significantly larger than those with red tongue（ 22. 32%）,dark purple tongue（ 5. 36 %） and light peeled tongue（ 21. 43%） on the 8 th day after chemotherapy. The number of patients with fine pulse（ 28. 57%） and slippery pulse（ 9. 82%） on the 8 th day after chemotherapy was significantly smaller than those with fine pulse（ 37. 50%） and slippery pulse（ 25. 89%） on the 8 th day before chemotherapy（ P 〈 0. 05）. The number of patients with fine and
作者
吕振选
田国防
李春青
吕朝凤
张清琴
Lyu Zhenxuan;Tian Guofang;Li Chunqing;Lyu Chaofeng;Zhang Qingqin(Department of Oncology ,Xinxiang Central Hospital ,Xinxiang 453000, China;Department of Oncology, The First Affiliated Hospital of Xingxiang Medical University ,Xinxiang 453100, China)
出处
《世界中医药》
CAS
2018年第4期897-899,903,共4页
World Chinese Medicine
基金
河南省医学科技攻关计划(2011020091)
关键词
培美曲塞
顺铂
化疗
原发性晚期非小细胞肺腺癌
中医证候
Pemetrexed
Cisplatin
Chemotherapy
Primary advanced non-small cell lung adenocarcinoma
TCM syndrome
