摘要
免疫逃逸在肿瘤的发生发展中发挥了重要作用,程序性细胞死亡受体1(PD-1)是在免疫反应中T细胞表面表达的免疫检查点抑制剂,主要由其配体PD-L1激活,PD-1/PD-L1信号通路主要通过降低T淋巴细胞活化、抑制T淋巴细胞增殖和诱导特异性T细胞凋亡而发挥负性调节的作用。在多种肿瘤细胞包括乳腺癌(尤其是具有高增殖指数的乳腺癌亚型)中,PD-1/PD-L1的表达都会上调,说明PD-1/PD-L1信号通路可能是主要的免疫逃逸机制之一。已有多项研究表明特异性抗体阻断PD-1或PD-L1对乳腺癌有一定疗效。
Immune escape plays an important role in occurrence and development of cancer, programmed cell death receptor-1（PD-1） is an immune checkpoint inhibitor expressed on T cells. PD-1 and its ligand PD-L1 may have negative regulatory effects by decreasing activation, inhibiting proliferation and inducing apoptosis on T cells. PD-1/PD-L1 pathway is considered to be a major mechanism of immune escape; it shows high expression in many tumors including breast tumor, especially in highly proliferative breast cancer. Anti-PD-1/PD-L1 specific antibodies have been proved to have certain curative effect on breast cancer.
作者
赵丹
王伏生
路晓庆
姚天婍
王静之
Zhao Dan, Wang Fusheng, Lu Xiaoqing, Yao Tianqi, Wang Jingzhi(Department of Breast Surgery, Second Hospital of Shanxi Medical University, Taiyuan 030001, Chin)
出处
《中国医药》
2018年第7期1106-1109,共4页
China Medicine
基金
山西省重点研发计划(一般)社会发展项目(2010703D321014-1)~~
