摘要
目的分析南京鼓楼医院抗真菌药物不良反应(ADR)发生的特点和规律,为临床合理用药提供参考。方法收集南京鼓楼医院2007年9月—2017年9月上报国家药品不良反应监测中心的149例有效的抗真菌药物ADR报告,分别从患者的性别、年龄、给药途径、药物剂型、合并用药、累及器官系统分布及临床表现、ADR的转归情况等进行统计分析。结果抗真菌药物所致的ADR患者男女比例为1∶1.22;60岁以上发生率最高(46例,30.87%)。引发ADR的主要给药途径为静脉滴注(98例,65.77%)。ADR报告涉及7种药物剂型,其中以粉针剂为主,占总剂型的34.23%。吡咯类的不良反应占88.59%,其中主要以伏立康唑为主,构成比为36.24%。未合并用药者为113例,占75.84%。所致ADR主要累及中枢及外周神经系统(49例,28.99%),其次为皮肤及其附件(34例,20.12%)等。ADR的转归以痊愈和好转为主。结论抗真菌药物发生ADR与多种因素相关,应严格控制药物的不合理使用,减少ADR发生。
Objective To analysis the characteristics and regularities of adverse drug reaction（ADR） of antifungals in Nanjing Drum Tower Hospital, and to provide reference for rational drug use in clinic. Methods 149 Cases of effective antifungals adverse reaction reports from September 2007 to September 2017 in Nanjing Drum Tower Hospital to National ADR Monitoring Center were selected and analyzed according to the patient＇s gender and age, medication methods, drug types, combination of drugs, involved organ system distribution and clinical manifestations, and ADR results. Results The ratio of male to female patients with adverse reactions caused by antifungal drugs was 1∶1.22. Patients over the age of 60 had the highest incidences（46 cases, 30.87%）. Intravenous administration（98 cases, 65.77%） was the main route. ADR reports involved 7 kinds of dosage forms, which mainly were powder injection, accounting for 34.23%. ADR reduced by pyrroles accounted for 88.59%, in which voriconazole had the highest incidences with the ratio of 36.24%. 113 Cases of patients were given single drugs, accounting for 75.84%. Organs/systems involved by ADR mainly were central and peripheral nervous system（49 cases, 28.99%）, followed by skin and its appendages（34 cases, 20.12%）, and so on. The outcome of ADR was mainly recovery and improvement. Conclusion Multiple factors contributed to the ADR of antifungals, therefore the irrational use of drugs e should be strictly controlled, in order to reduce the occurrence of ADR.
作者
宋雪敏
张海霞
SONG Xue-min;ZHANG Hai-xia(Department of Pharmacy, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China)
出处
《现代药物与临床》
CAS
2018年第5期1267-1272,共6页
Drugs & Clinic
