摘要
抑郁症是一种以情绪低落、自我价值感降低、快感缺失为主要症状的精神类疾病,准确可靠的动物模型可为研究抑郁症的发病机制及抗抑郁药物的筛选提供帮助。本文通过理想动物模型建立的三个原则(表面效度、结构效度和预测效度),综述了几种常见的动物模型及其特点。慢性不可预知温和刺激是物理因素致抑郁的代表,能模拟人类日常生活中的应激状态;习得无助的发病症状与人类相似,但持续时间较短;社会挫败模型模拟慢性应激中的社会属性,耗时较长;糖皮质激素重复注射模型建模效率很高,不能完全排除药物副作用对实验的影响;嗅球切除模型动物较好地模拟人类的应激状态,但手术死亡率高。
Major depression disease is a kind of psychic condition characterized by listlessness, diminished selfevaluation, and anhedonia. A reliable animal model can provide help for the study of mechanism of the diseases and the screening tests for antidepressant drugs. Based on the principles of ideal animal model establishment （facial validity, structure validity and predictive validity}, this article has reviewed some eommon animal models and their characters. Chronic, unpredictable mild stress（CUMS） model is the representative model of the physical factor induced animal models of depression, which can sinmlate the common stress state encountered by humans in the daily life; Learned helpless（LH） model is characterized by the presence of similar symptoms wilh human depression onset, but the maintenance time is short; Social defeat model puts emphasis on the mimicry of social property during the stress process, but the establishment of the model is a time-consuming process; Olfactory bulbectomy model（OBX） processes the same advantage, but the mortality rate of animals remains high after undergoing the surgical procedure.
作者
闫惠淳
王通宇
温歌华
吴旭
YAN Hui-chun;WANG Tong-yu;WEN Ge-hua;WU Xu(2014 Department of Stomatology;2014 Clinical Medicine of Seven-year Program;Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122)
出处
《解剖科学进展》
2018年第3期326-329,333,共5页
Progress of Anatomical Sciences
基金
国家自然科学基金(81171032、81671867)
辽宁省教育厅科学研究一般项目(L2014316)
辽宁省科学技术基金项目(2015020514)
