摘要
目的提高姜黄素(curcumin,CUR)的溶出度。方法采用湿法研磨技术制备姜黄素纳米混悬剂(curcumin nanosuspension,CUR-NS),采用喷雾干燥技术固化CUR-NS。结果制得的CUR-NS为均匀的黄色混悬液,平均粒径为288 nm,跨度为0.702。喷雾干燥得到的CUR-NS喷干粉(curcumin spray dried powder,CUR-SDP)能够保持CUR-NS的粒度分布。CUR-SDP显著提高了CUR的体外溶出度。在20 min时CUR-SDP完全溶出,而CUR原料药(curcumin bulk drug,CUR-Bulk)和物理混合物(curcumin physical mixtures,CUR-PM)的累积溶出度只有49.2%和52.7%。结论通过湿法研磨技术降低药物粒径,能够显著提高水难溶性药物CUR的体外溶出度。
Objective To improve the dissolution of curcumin（ CUR）. Methods Curcumin nanosuspension（ CUR-NS） was prepared by wet grinding technology,and CUR-NS was solidified by spray drying technique. Results The resulting CUR-NS was homogeneous yellowsuspension with a mean particle size of288 nm and the span of 0. 702. The CUR-NS spray dried powder（ CUR-SDP） obtained by spray drying could maintain the particle size distribution of CUR-NS. CUR-SDP significantly increased the in vitro dissolution of CUR. CUR-SDP was completely dissoluted within 20 min,while the accumulated dissolution of CUR bulk drug（ CUR-Bulk） and the physical mixture（ CUR-PM） was only 49. 2% and 52. 7%. Conclusions The in vitro dissolution of poorly water soluble drug CUR can be significantly improved by reducing the particle size of the drug through wet grinding technology.
作者
郭奇喆
黄浩
何海冰
张宇
蔡翠芳
唐星
GUO Qizhe;HUANG Hao;HE Haibing;ZHANG Yu;CAI Cuifang;TANG Xing(School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;Shenyang Dongxing Pharmaceutical Technology Co. ,Ltd. , Shenyang 110179, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2018年第5期339-343,共5页
Journal of Shenyang Pharmaceutical University
