摘要
目的:比较布洛芬混悬液与吲哚美辛栓治疗小儿发热的疗效。方法:选取2017年8月至2017年12月复旦大学附属金山医院收治的发热患儿96例作为研究对象,根据就诊先后顺序分为观察组和对照组,每组48例。观察组患儿给予布洛芬混悬液进行降温治疗,对照组患儿给予吲哚美辛栓。对比观察两组患儿的体温变化、临床疗效及不良反应发生情况的差异。结果:观察组患儿不同时间体温明显低于对照组,差异均有统计学意义(P<0.05);观察组患儿的总有效率为93.8%(45/48),明显高于对照组的83.3%(40/48),差异有统计学意义(P<0.05);观察组患儿不良反应发生率为6.2%(3/48),明显低于对照组的14.6%(7/48),差异有统计学意义(P<0.05)。结论:布洛芬混悬液治疗小儿发热的疗效显著,可调节患儿体温,且不良反应较少。
OBJECTIVE： To probe into the efficacy between ibuprofen suspension and indomethacin suppositories in treatment of fever in children. METHODS： 96 child patients with fever admitted into Jinshan Hospital of Fudan University from Aug. 2017 to Dec. 2017 were selected and divided into observation group and control group via the sequences of doctor visiting,with 48 cases in each. The observation group was given ibuprofen suspension for hypothermia,while the control group was treated with indomethacin suppositories. Changes of temperature,clinical efficacy and incidences of adverse drug reactions of two groups were observed and compared. RESULTS： The temperatures of child patients at different time-points in observation group were significantly lower than those of the control group,with statistically significant differences（ P〈0. 05）; the total effective rate of observation group was93. 8%（ 45/48）,which was significantly higher than that of the control group（ 83. 3%,40/48）,with statistically significant difference（ P〈0. 05）; the incidence of adverse drug reactions of observation group was 6. 2%（ 3/48）,which was significantly lower than that of the control group（ 14. 6%,7/48）,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of ibuprofen suspension in treatment of fever in children is remarkable,which can regulate patients＇ temperatures,with few adverse drug reactions.
作者
傅珺璐
FU Junlu(Dept. of Pharmacy, Jinshan Hospital of Fudan University, Shanghai 201508, Chin)
出处
《中国医院用药评价与分析》
2018年第5期619-620,623,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
发热
疗效
布洛芬
吲哚美辛
Fever
Efficacy
Ibuprofen
Indomethacin
