摘要
目的：探讨小儿肺炎支原体肺炎确诊前先用大环内脂类药物临床治疗的疗效。方法：对就诊时未明确病原体的46肺炎患儿先用大环内脂类药物治疗，给予阿奇霉素5～10mg／（kg·d）或红霉素25mg／（kg·d）静脉用药。经检测肺炎支原体抗体（MP-IgM）阳性的32例，继续用阿奇霉素治疗（疗程满7～10d后改13服，吃3d停4d）3～4周；并设确诊的肺炎支原体肺炎30例为对照组。结果：肺炎支原体肺炎确诊前先用大环内脂类药物治疗，比确诊后再换用大环内脂类抗生素治疗在发热、咳嗽、肺部体征改善、消失方面均有显著效果，两组治愈率经统计学处理后进行比较，差异有统计学意义（P〈0．05）；而普通肺炎患儿也未出现病情恶化，同期治愈。结论：肺炎支原体肺炎未确诊时先用大环内脂类药物治疗的疗效满意，可缩短病程，减少并发症的发生，有较高的临床实用价值。
Objective： To investigate the clinical effect of macroflides drugs on the treatment of children with mycoplasma pneumoniae pneumonia. Methods： 46 children with pntmaonia were treated with injection of azithromycin 5-10mg（kg·d） or erythromycin 25 mg （kg·d） since the admitted day before etiology diagnosis. The same treatment eontinued in the 32 cases, who were MP-IgM test positive, for 7-- 10 days, after that they were treated with oral azithromycin for 3-4 weeks. 30 children （ocmtrol group） with mycoplarna pneumoniae pneumonia were treated with azithromycin or erythromycin after etiology diagnosis. Results： There is no significant difference in cure rate between the two groups. But it takes less time for the temperature drop to normal and cough and role to be disappeared as well as that has lower rate of complications than the control group （P〈0.05）. And meanwhile that is same for the children with common pneumonia, who did not get worse, but got cured at the same time. Conclusion： It can shorten disease courses and decrease the rate of complications if the patients were treated with macroflides durgs before etiology diagnosis, thus it has very good clinical effect on children with mycoplasma pneumoniae pneumonia.
出处
《现代预防医学》
CAS
北大核心
2006年第9期1693-1694,共2页
Modern Preventive Medicine
关键词
肺炎支原体
确诊前
大环内脂类药物
Mycoplasma Pneumoiae
Pneumonia
Etiologydiagnose
Macroflides
