摘要
目的:分析小儿社区获得性肺炎(CAP)住院前后抗生素应用的相关性,促进抗生素的合理使用。方法:对577例住院治疗的CAP患儿住院前后应用抗生素的种类、药物更换情况及临床治疗效果进行分析。结果:577例患儿中,住院前231例(40.0)应用β-内酰胺类抗生素,326例(56.5)应用大环内酯类抗生素,20例(3.7)应用其它种类抗生素;住院后应用β-内酰胺类抗生素的患儿中有118例(51.1)更换为大环内酯类抗生素,74例(32.0)更换为其它β-内酰胺类抗生素,应用大环内酯类抗生素的患儿中有236例(73.3)更换为β-内酰胺类抗生素,39例(11.9)更换为其它大环内酯类抗生素,157例(27.2)患儿联合应用了大环内酯类和β-内酰胺类抗生素,67例(11.6)患儿抗生素的更换过早。联合应用抗生素组的住院天数、临床治愈率与其他组比较差异无统计学意义。结论:在小儿CAP治疗中,院内抗感染药物的选择受院前抗生素使用种类的影响,未获得病原学证据前,应避免频繁更换抗生素。
Objective：To analyze the correlation of the antibiotics used pre-admission and inhospital and to advance the rational utilization of antibiotics in the treatment of children with community-acquired pneumonia （CAP）. Methods： The medical records of 577 hospitalized cases with child CAP were collected with the usage of antibiotics, hospital days and clinical cure rate reviewed and analyzed. Results： Among 577 cases, 231 cases （40.0%） were treated with β-lactam antibiotics, 326 cases （56.5%） treated with macrolide antibiotics and 20 cases （3.7%） treated with other species of antibiotics before admission. Among 231 cases treated with 13-1actam antibiotics, 118 cases （51.1% ） were treated with macrolide antibiotics instead of 13-1actam antibiotics, 74 cases （ 32.0% ） were treated with other species of β-lactam antibiotics, and 39 cases were treated with their primary protocol after admitted to our hospital. Among 326 cases treated with macrolide antibiotics, 236 cases （73.3%） were treated with β-lactam antibiotics instead of macrolide antibiotics, 39 cases （ 11. 9% ） were treated with other species of macrolide antibiotics, and 48 cases were treated with their primary protocol. One hundred and fifty-seven of 577 cases （27.2%） were treated with the combined usage of macrolide antibiotics and β-lactam antibiotics. Sixty-seven of 577 cases （ 11.6% ） had changed their primary protocol inappropriately. There was no significant difference in the hospital days and clinical cure rate between the three groups. Conclusions ： The in-hospital utilization of antibiotics in the treatment of children with CAP was influenced by the species of antibiotics given before admission. Unless the evidence of the etiology of patients obtained, their prehospital antibiotic therapy shouldn＇ t be changed frequently.
出处
《儿科药学杂志》
CAS
2008年第6期16-18,共3页
Journal of Pediatric Pharmacy
关键词
社区获得性肺炎
抗生素
小儿
相关性
Community-acquired pneumonia
Antibiotics
Children
Correlation
