摘要
背景与目的目前检测非小细胞肺癌(non-small cell lung cancer,NSCLC)术后患者复发转移的方法均具有一定的滞后性及片面性。本研究总结分析了30例NSCLC患者外周血循环肿瘤细胞(circulating tumor cell,CTC)及成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)表达情况与临床病理之间的关系,以期能够为肿瘤复发转移的检测提供新思路。方法分析北京协和医院胸外科2016年11月-2017年6月30例NSCLC患者临床资料及CTC检测数据并进行相关性分析。结果相关性数据分析可得,外周血CTC细胞阳性率与吸烟史相关(P=0.016),病理类型与CTC阳性率及FGFR1表达情况之间无明显关联(P=0.202,P=0.806),不同类型CTC细胞FGFR1表达情况并无明显差异(P=0.094)。结论 CTC阳性率与NSCLC患者吸烟史相关,不同病理类型NSCLC中CTC分类及FGFR1表达情况无明显差异,不同类型CTC之间FGFR1表达情况无明显差异。我们期待着更大样本量及纳入随访数据后可得出与CTC及FGFR1基因表达相关的更多具有临床应用意义的结论。
Background and objective The methods of detection for recurrence and metastasis in patients with non-small cell lung cancer（NSCLC） have hysteresis and one-sidedness. This study summarizes the relationship between the circulating tumor cell（CTC） in peripheral blood, expression of fibroblast growth factor receptor 1（FGFR1） and clinic pathological features in 30 patients with NSCLC so as to provide new ideas for the detection of tumor recurrence and metastasis. Methods To analyze the clinical data and CTC detection data of 30 cases of NSCLC in Department of Thoracic Surgery, Peking Union Medical College Hospital from November 2016 to June 2017. Results Data analysis showed that the positive rate of CTC in peripheral blood was remarkably correlated with the smoking history（P=0.016）. There was no significant correlation among the pathological type and CTC positive rate and the expression of FGFR1（P=0.202, P=0.806）. There was no significant difference in the expression of FGFR1 in different type CTC cells（P=0.094）. Conclusion The positive rate of CTC was significantly correlated with the smoking history of patients with NSCLC. There was no significant difference in CTC classification and FGFR1 expression in different pathological types of NSCLC. There was no significant difference in the expression of FGFR1 between different types of CTCs. We look forward to a larger sample size and inclusion of follow-up data to arrive at more clinically relevant conclusions about CTC and FGFR1 gene expression.
作者
刘磊
黄诚
李力
梁乃新
李单青
Lei LIU;Cheng HUANG;Li LI;Naixin LIANG;Shanqing LI(Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100730, China;Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China)
出处
《中国肺癌杂志》
CAS
CSCD
北大核心
2018年第5期365-374,共10页
Chinese Journal of Lung Cancer
基金
北京协和医学院青年教师项目(2014zlgc0717)
北京市自然科学基金面上项目(7182132)
北京市科委重大课题(Z171100002017013)
北京市科委“首都特色”临床专项(Z151100004015157)
北京协和医院青年基金(PUMCH-2016-2.25,HI626500)
小规模特色办学项目(2014zlgc0135)资助
关键词
肺肿瘤
循环肿瘤细胞
成纤维细胞生长因子受体1
吸烟史
转移
Lung neoplasms
Circulating tumor cell
Fibroblast growth factor receptor 1
Smoking history
Metastasis
