摘要
目的分析原发性胃癌患者手术后真菌感染的部位、菌株分布以及引起感染的影响因素,为原发性胃癌患者治疗以及真菌治疗提供有效的临床理论依据。方法选取2012年2月-2017年4月于医院接受治疗的494例原发性胃癌患者为研究对象,回顾性分析患者临床资料,分析感染患者真菌感染部位、菌株分布,并对引起真菌感染的影响因素进行单因素以及多因素Logistic回归分析。结果 494例原发性胃癌患者共有23例手术后真菌感染,真菌感染率为4.66%,共检出51株真菌,其中白假丝酵母29株,占56.86%;感染部位以呼吸道和消化道为主,占47.83%和43.48%;Logistic多因素回归分析结果显示,术前有吸烟史、年龄≥60岁、术后细菌感染是造成原发性胃癌患者手术后真菌感染独立影响因素。结论原发性胃癌患者手术后真菌感染率较高,同时术前有吸烟史、年龄≥60岁、术后细菌感染是造成原发性胃癌患者手术后真菌感染的独立影响因素,临床治疗时应该根据上述因素进行有效预防及治疗。
OBJECTIVE To investigate the sites of postoperative fungal infections,species of pathogens and influencing factors for the infection in patients with primary gastric cancer so as to provide effective theoretical basis for clinical treatment of the patients with gastric cancer and fungal treatment.METHODS A total of 494 patients with primary gastric cancer who were treated in the hospital from Feb 2012 to Apr 2017 were recruited as the study objects,the clinical data of the patients were retrospectively analyzed.The sites of fungal infection and species of pathogens were observed,and the univariate analysis and multivariate logistic regression analysis were performed for the influencing factors for the fungal infections.RESULTS Of the 494 patients with primary gastric cancer,23 had postoperative fungal infections,with the infection rate 4.66%.Totally 51 strains of fungi were isolated,of which 29（56.86%）were Candida albicans.The patients with respiratory tract infection accounted for 47.83%,the patients with gastrointestinal tract infection 43.48%.The result of multivariate logistic regression analysis showed that preoperative smoking history,no less than 60 years of age and postoperative bacterial infection were the independent influencing factors for the postoperative fungal infections in the patients with primary gastric cancer.CONCLUSION The incidence rate of postoperative fungal infections is high among the patients with primary gastric cancer.The preoperative smoking history,no less than 60 years of age and postoperative bacterial infections are the independent influencing factors for the postoperative fungal infections.It is necessary for the hospital to take effective prevention and treatment measures according to the above factors.
作者
马杰
姚林果
刘世君
丁西平
孟繁春
李永生
MA Jie;YAO Lin-guo;LIU Shi-jun;DING Xi-ping;MENG Fan-chun;LI Yong-sheng(Shengli Oilfield Central Hospital, Dongying , Shandong 257000, Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第9期1324-1326,共3页
Chinese Journal of Nosocomiology
关键词
原发性胃癌
术后
真菌感染
独立危险因素
状况研究
Primary gastric cancer
Postoperative
Fungal infection
Independent risk factor
Status study
