摘要
目的:探讨多药耐药(MDR_1)基因、多药耐药相关蛋白(MRP)基因在非小细胞肺癌(NSCLC)中的表达情况及其与组织类型的关系。方法:用逆转录多聚酶链反应(RT-PCR)方法检测新鲜肺癌组织标本。结果:48例NSCLC标本MDR_1、MRP基因阳性表达率分别为62.5%、66.7%,二种基因共同表达率为43.8%。肺鳞癌MRP基因表达明显高于腺癌(P<0.01),而鳞癌与腺癌之间MDR_1基因表达无显著性差异(P>0.05)。结论:MDR_1、MRP基因可以共同或分别存在于肺癌组织中,肺鳞癌MRP基因表达率较腺癌高。
Objective:To investigate the expression of multidrug resistance (MDR1 ) gene and multidrug resistance-associated protein (MRP) gene in patients with non-small-cell lung cancer (NSCLC) and its relation to histopathological type. Methods: The MDR1 and MRP genes were determined by reverse transcription-polymerase chain reaction (RT-PCR) in 48 NSCLC specimens.Results:The positive rates of the MDR1 and MRP gene expression were 62.5% and 66.7% respectively in the 48 patients. Twenty-one of the 48 NSCLCs (43.8%) expressed both MDR1 and MRP genes. The positive rates of the MRP gene expression in squamous cell carcinoma was significantly higher than those in adenocarcinoma (P < 0.01 ) ,and there was no significant difference in MDR1 gene expression between the two groups (P >0.05). Conclusion: The MDR1 and MRP gene expressions were both or respectively in the NSCLCs. The incidence of the MRP gene expression in squamous cell carcinoma was higher than that in adenocarcinoma.
出处
《天津医药》
CAS
2000年第12期738-739,共2页
Tianjin Medical Journal
