摘要
目的利用脾氨肽联合糖皮质激素对过敏性鼻炎-哮喘综合征患儿进行治疗,研究患儿外周血清中Th1/Th2细胞因子的表达水平。方法选取2013年6月-2016年6月在邢台市第三医院治疗的过敏性鼻炎-哮喘综合征患儿182例,随机分为对照组和试验组,每组各91例。对照组采用糖皮质激素单独治疗,试验组采用脾氨肽联合糖皮质激素综合治疗。治疗2个月后对患儿血清中白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、γ-干扰素(IFN-γ)、TNF-β水平进行检验。结果治疗后,试验组IL-4,IL-5浓度(41.68±3.82)pg/ml、(40.68±5.83)pg/ml要明显低于对照组(49.76±8.01)pg/ml、(45.02±7.15)pg/ml,IFN-γ及TNF-β浓度(30.57±1.34)ng/ml、(63.74±13.51)ng/ml高于对照组的(23.73±1.67)ng/ml、(57.68±17.56)ng/ml,差异有统计学意义(P<0.05);试验组显效64例(70.32%),高于对照组的42例(46.15%),差异有统计学意义(P<0.05),试验组总有效82例(90.11%),高于对照组的67例(73.63%),差异有统计学意义(P<0.05);不良反应比较,试验组MPP次数明显低于对照组,差异有统计学意义(P<0.05);试验组发热、咳嗽、扁桃体肿大和肺内啰音等症状持续时间明显低于对照组,差异有统计学意义(P<0.05)。结论脾氨肽联合糖皮质激素能够有效治疗过敏性鼻炎-哮喘综合征患儿,影响Th1/Th2类细胞表达,抑制机体炎症反应,疗效显著。
Objective To treat the children with allergic rhinitis and asthma syndrome by spleen aminopeptide combined with glucocorticoid,research the expression levels of Th1/Th2 cytokines in peripheral blood of these children. Methods From June 2013 to June 2016,182 children with allergic rhinitis and asthma syndrome treated in the third Hospital of Xingtai were selected and randomly divided into control group and experimental group,91 children in each group. The children in control group were treated by glucocorticoid,and the children in experimental group were treated by spleen aminopeptide combined with glucocorticoid. After two months of treatment,the levels of serum interleukin-4(IL-4）,interleukin-5(IL-5）,interferon-γ(IFN-γ）,and tumor necrosis factor-β(TNF-β） were detected.Results After treatment,the levels of serum IL-4 and IL-5 in experimental group were(41. 68±3. 82） pg/ml and(40. 68±5. 83） pg/ml,respectively,which were statistically significantly lower than those in control group [(49. 76±8. 01） pg/ml and(45. 02±7. 15） pg/ml],respectively(P〈0. 05）; the levels of serum IFN-γ and TNF-β in experimental group were(30. 57±1. 34） ng/ml and(63. 74±13. 51） ng/ml,respectively,which were statistically significantly higher than those in control group [(23. 73±1. 67） ng/ml and(57. 68±17. 56） ng/ml],respectively(P〈0. 05）. The effective rate in experimental group was 70. 32%(64 children）,which was statistically significantly higher than that in control group(42 children,46. 15%）(P 〈 0. 05）. The total effective rate in experimental group was 90. 11%(82 children）,which was statistically significantly higher than that in control group(67 children,73. 63%）(P〈 0. 05）. The incidence rate of MPP in experimental group was statistically significantly lower than that in control group(P〈 0. 05）. The duration time of fever,coughing,antiadoncus,and pulmonary rales in experimental group was statistically significantly lower than that in control group(P 〈 0. 05）.Conclusion
作者
郝现伟
闫哲
张丽
田艳勋
孙丽英
HAO Xian-Wei;YAN Zhe;ZHANG Li(Department of Pediatrics, the Third Hospital of Xingtai, Xingtai, Hebei 054000, Chin)
出处
《中国妇幼保健》
CAS
2018年第9期2007-2010,共4页
Maternal and Child Health Care of China
基金
河北省邢台市科技支撑计划项目(2017ZC078)
