摘要
中枢神经系统疾病严重影响人类的生命健康,但其发病机制尚不完全清楚。目前,用于治疗中枢神经系统疾病药物主要为受体调节剂、神经递质抑制剂等,其副作用较大,临床用于治疗的药物较为缺乏。研究表明中药动物药主要含蛋白、多肽及小分子化合物等,作用于中枢神经系统,具有镇静、抗惊厥、改善腩组织等药理作用。大量的研究表明动物药具有活性强、疗效佳的特性,在研究开发治疗中枢神经系统疾病药物方面具有广阔的前景。基于此,该文在系统查阅文献的基础上,对具有息风止痉功效中药动物药的活性成分及其在中枢神经系统疾病癫痫、脑缺血的主要药理作用进行了综述,探讨了其研究价值及应用前景。结果表明动物药蛋白质、多肽的研究较为浅显,部分动物药的研究尚处于空白点,笔者认为动物药氨基酸、小分子化合物的研究应转移至寡肽、短肽上,采用先进的蛋白质提取、分离技术,进行蛋白多肽类成分的结构鉴定与药效研究.利用生物制品技术方法开发治疗中枢神经系统疾病的肽类生物制品。该文可为开发治疗中枢神经系统疾病的动物药制品研究提供思路与借鉴。
The human health is seriously 'affected by central nervous system(CNS) diseases, but the pathogenesis of" CNS diseases is still not cmnpletely clear. Currently, the drugs used to treat CNS diseases are mainly receptor modulators and neurotransmitter inhibi- tors, which have serious side effects; and there are short of drugs for treating CNS diseases clinically. Studies suggest that animal medi- cines mainly include protein, polypeptide and small-molecule compounds, and have such pharmacological effects in calming, resisting convulsions and improving brain tissues. Plenty of studies suggest that animal medicines usually have a strong activity and good curative effect on these diseases, with a promising prospect in research mad development of drugs treating CNS diseases. Based on systematic re- views of literatures, this paper summarizes active ingredients and main pharmacological effects of animal medicines in " extin lishing wind to arrest convulsions" for the CNS diseases, epilepsy and cerebral ischemia, and discusses their study value and application pros- pects. The results showed that the studies of protein and peptides were relatively simple, and some animal medicines were still blank. The authors believed that amino acids and small molecular compounds should be transferred to oligopeptide, advanced protein extraction and separation techniques shall be adopted for identifying the protein polypeptide composition structure and studying the efficacy, and the methods of biological technology were used to develop peptide biological products for the treatment of CNS diseases. This papercould provide ideas and reference for developing animal medicine products for the treatment of CNS diseases.
作者
余志杰
李劲松
彭伟
王平
熊亮
刘玉杰
徐颖
孙涛
YU Zhi-jie1, LI Jin-song2, PENG Wei1, WANG Ping1 , XIONG Liang1 , L1U Yu-jie1 , XU Ying1, SUN Tao1(1. Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Chit~a ; 2. The First People's Hospital of Guangyuan City, Guangyuan 628017, Chin)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第6期1086-1092,共7页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(81773906)
广元市科技局科技支撑计划项目(14KJZCS003)
四川省中医药管理局项目(2014F013,2016Q053)
成都市科技局科技惠民计划项目(2016-HM01-00356-SF)
关键词
息风止痉
动物药
活性成分
中枢神经系统疾病
药理作用
extinguishing wind to arrest convulsions
animal medicines
active ingredient
central nervous system disease
pharmacological effect