摘要
目的调查住院中老年男性非前列腺癌(PCa)患者的前列腺特异性抗原(PSA)及其相关指标的年龄特异性分布情况,研究其与年龄(或前列腺体积)变化的关系。方法 2015年1月至2017年12月于湖北省中医院住院的369例男性非PCa患者,按年龄分成4组:50~59岁患者86例;60~69岁患者130例;70~79岁患者80例;80~89岁患者73例。测定血清总PSA(tPSA)、游离PSA(fPSA)及前列腺体积,计算出游离和总前列腺特异性抗原比值(F/T)、前列腺特异性抗原密度(PSAD)和(F/T)/PSAD。采用Pearson相关分析法分析tPSA与患者年龄、前列腺体积的关系。采用Pearson相关分析法分析F/T、PSAD和(F/T)/PSAD与患者年龄的关系。结果血清tPSA与患者的年龄、前列腺体积之间均呈正相关性(r分别为0.328、0.695,P均<0.001),且血清tPSA与前列腺体积之间的相关性更显著;F/T与患者年龄呈负相关性(r=-0.144,P<0.05);PSAD与患者年龄呈正相关性(r=0.170,P<0.01);(F/T)/PSAD与患者年龄呈负相关性(r=-0.199,P<0.001)。结论中老年男性非PCa住院患者的血清tPSA与年龄、前列腺体积均呈正相关性,而其F/T和(F/T)/PSAD与年龄呈负相关性,PSAD与年龄呈正相关性。
Objective To investigate the age specific distribution of prostate specific antigen（PSA）and its related indicators in middle-aged and elderly men without prostate cancer（PCa）,and to study their relationship with age（or prostate volume）and their significance in screening PCa.Methods From January 2015 to December 2017,369 non-PCa male patients in Hubei Provincial Traditional Chinese Medical Hospital were divided into four groups according to age：50-59 years old（86 cases）;60-69 years old（130 cases）;70-79 years old（80 cases）;80-89 years old（73 cases）.Serum tPSA,free PSA（fPSA）and prostate volume were measured,and F/T,PSAD and（F/T）/PSAD were calculated.The relationship between tPSA and age,volume of prostate were analyzed by Pearson correlation analysis.The relationship between age and F/T,PSAD,（F/T）/PSAD were analyzed by Pearson correlation analysis. Results There was a positive correlation between serum tPSA and age,prostate volume（r=0.328,0.695;P〈0.001）,and the correlation between serum tPSA and prostate volume was more significant.There was a negative correlation between F/T and age（r=-0.144,P〈0.05）;the correlation between PSAD and age of the patients was positive（r=0.170,P〈0.01）;（F/T）/PSAD was negatively correlated with age（r=-0.199,P〈0.001）.Conclusions There is a positive correlation between serum tPSA and age,prostate volume in middleaged and elderly men without PCa,while F/T and（F/T）/PSAD are negatively correlated with age.PSAD is positively correlated with age.
作者
朱旋
张忠民
胡少炜
曾令启
高文喜
ZHU Xuan;ZHANG Zhong -min;HU Shao -wei;ZENG Ling- qi;GAO Wen -xi(Department of Urology,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061,China)
出处
《现代泌尿生殖肿瘤杂志》
2018年第2期98-101,共4页
Journal of Contemporary Urologic and Reproductive Oncology
