摘要
目的探讨我院17年间前列腺癌患者的临床特征如发病年龄、前列腺特异性抗原(PSA)、Gleason评分、分期及穿刺阳性率等的变化。方法采用回顾性分析,对广州市第一人民医院2000—2016年泌尿外科1 231例穿刺活检的患者及564例前列腺癌患者资料进行分析,按患者的诊断时间分为A组(2000—2005年)、B组(2006—2009年)、C组(2010—2012年)、D组(2013—2014年)、E组(2015—2016年),对各组的年龄、PSA、Gleason评分、分期及穿刺活检阳性率进行统计学分析,看各组间的各项指标差异是否有统计学意义。结果5组年龄均值(73.36,73.74,72.05,73.40,72.96岁)、PSA均值(208.95,190.25,173.19,283.54,148.69μg/L)及穿刺活检阳性率均值(48%,43%,37%,44%,39%)差异均无统计学意义(P均>0.05)。5组Gleason均值为6.80,6.73,7.12,6.93,7.32,A、B组和E组Gleason评分差异有统计学意义(P均<0.05),其余各组Gleason评分差异均无统计学意义(P均>0.05)。TNM分期转化得分5组均值为5.96,6.80,7.05,7.31,6.83,A和C组、D组、E组差异均有统计学意义(P均<0.05),其余各组TNM分期转化得分差异均无统计学意义(P均>0.05)。结论 17年间前列腺癌患者诊断时的年龄、PSA水平及穿刺活检阳性率没有显著变化。
Objective To investigate changes of inpatients with prostate cancer in the last 17 years such as age of onset,prostate specific antigen（ PSA）,Gleason score,prostate cancer staging and positive rate of prostate biopsy. Methods A retrospective analysis was conducted in 1 231 cases of biopsy patients of urology and 564 patients with prostate cancer who were hospitalized in the First People’s Hospital of Guangzhou from 2000 to 2016. According to the time of diagnose. All the patients were divided into five groups： group A（ 2000-2005）,group B（ 2006-2009）,group C（ 2010-2012）,group D（2013-2014） and group E（2015-2016）. The age,PSA,Gleason score,staging and positive rate of prostate biopsy were compared to realize whether the indicators of the differences between groups was statistically significant. Results In five groups,means of age,PSA,Gleason score and prostate biopsy positive rate are respectively 73. 36,73. 74,72. 05,73. 40,72. 96 years; 208. 95, 190. 25, 173. 19, 283. 54, 148. 69 μg/L; 6. 80, 6. 73, 7. 12, 6. 93, 7. 32; 5. 96, 6. 80,7. 05,7. 31,6. 83 and 48%,43%,37%,44%,39%. There was no significant difference in age,PSA and positive rate of prostate biopsy（ P 〉 0. 05）. The Gleason scores of group A and group E,group B and group E were statistically significant（ P 〈 0. 05）,while the other groups had no significant differences in Gleason score（ P 〉 0. 05）. There were statistical significance in TNM staging score between group A and group C,group D,group E（ P 〈 0. 05）,while the other groups had no statistical significance（ P 〉 0. 05）. Conclusion There are no change of prostate cancer patients in diagnosis of age,PSA levels and positive rate of prostate biopsy in the past 17 years.
作者
曾维威
谢克基
韦兴华
莫灿程
汤平
ZENG Weiwei;XIE Keji;WEI Xinghua;MO Cancheng;TANG Ping(Department of Urology,Guangzhou First People’s Hospital,Guangzhou Medical University,Guangzhou 510180,China)
出处
《广州医药》
2018年第3期5-9,共5页
Guangzhou Medical Journal
