摘要
帕金森疾病(Parkinson’s disease,PD)是一种神经退行性疾病,现多认为是遗传和环境因素相互作用的结果。典型特征是黑质纹状体中多巴胺神经元丧失以及多巴胺缺乏相关的典型帕金森运动特征。动物模型在阐明PD的发病机制、测试新的治疗方案及药物的研究中,具有十分重要的作用。啮齿类动物、树鼩和灵长类动物等采用不同造模方法所建立的PD动物模型都拥有自己的优势和局限性,所表现出的临床特征和病理机制与人类有所不同。因此,在科学研究中选择所需使用的模型时必须仔细考虑。本文就主要神经毒素及转基因PD动物模型的相关研究进展进行综述。
Parkinson＇s disease（PD） is a progressive neurodegenerative disorder,with an etiology that is now considered to be due to interaction between genetic and environmental factors. Typical PD features include loss of dopaminergic neurons in the nigrostriatal region,with typical motor traits of PD associated with dopamine deficiency.Animal models have contributed to determining PD etiology and pathogenesis,as well as testing new therapeutic schedules and novel drug research. Rodents,tree shrews,primates,and other animal models of PD have been established by different method. These models each have their own advantages and limitations,showing different clinical features and pathological mechanisms to those in humans. Therefore,the appropriate model for scientific research must be carefully considered. This article reviews the main neurotoxic and transgenic models of PD.
作者
张志成
袁圆
王璇
宋庆凯
代解杰
ZHANG Zhicheng;YUAN Yuan;WANG Xuan;SONG Qingkai;DAI Jiejie(Kunming Medical University,Kunming 650500,China.2.Center of Tree Shrews Germplasm Resource,Instituteof Medical Biology,Chinese Academy of Medical Sciences/Peking Union Medical College;Yunnan Key Laboratory ofMajor Infectious Diseases Vaccine Development,Kunming 65011)
出处
《中国比较医学杂志》
CAS
北大核心
2018年第5期21-27,共7页
Chinese Journal of Comparative Medicine
基金
云南省科技人才和平台计划项目(编号:2017HC019)
云南省重点实验室运行补助专项(编号:2017DG008)
云南省重大科技专项(编号:2017ZF007)
