摘要
[目的]探讨血浆脑钠肽(BNP)在内镜治疗食管胃底静脉曲张后的意义。[方法]将140例肝硬化患者分治疗组(n=87,62.1%)和非治疗组(n=53,37.9%),检测及比较2组间BNP、Child-Pugh分级及其他相关指标。[结果]治疗组与非治疗组间年龄、性别、病程、Child-Pugh分级、总胆红素、白蛋白、谷草转氨酶、谷丙转氨酶、谷氨酰转肽酶、凝血酶原时间、高血压、腹水、门脉血栓比较均差异无统计学意义;治疗组BNP为89.80(41.70～151.80)pg/ml,非治疗组为130.4(86.4～185.15)pg/ml,2组比较差异有统计学意义(P<0.05)。[结论]BNP对肝硬化食管胃底静脉曲张内镜治疗后有良好效果评价,并有助于肝硬化病情严重程度判断。
[Objective]To evaluate the predicting effect of plasma brain natriuretic peptide（BNP）in endoscopic treatment of esophageal and gastric varices.[Methods]The totals of 140 patients with liver cirrhosis were divided into treatment group（n= 87,62.1%）and non-treatment group（n= 53,37.9%）.The BNP,Child-Pugh score and other related indexes were detected and compared between the two groups.[Results]The average BNP level in the treatment group was 89.80（41.70-151.80）pg/ml and 130.4（86.4-185.15）pg/ml in the non-treatment group,the difference was statistically significant（P〈0.05）.The age,sex ratio,duration of disease,Child-Pugh score,total bilirubin,albumin,aspartate aminotransferase,alanine aminotransferase,glutamyl transpeptidase,prothrombin time,hypertension,ascites,portal vein thrombosis showed no significant differences.[Conclusion]BNP can well evaluate the effect of endoscopic treatment of esophageal and gastric varices,and it is helpful to judge the severity of cirrhosis.
作者
陈长旦
张文
郑秀金
CHEN Chang-dan1 , ZHANG Wen2 , HENG Xiu-jin1(1 Department of Gastroenterology,Ningde City Hospital Affiliated to Fujian Medical University, Fujian 352100, China; 2 Department of Pneumology, Ningde City Hospital Affiliated to Fujian Medical University, Fujian 352100, Chin)
出处
《临床消化病杂志》
2018年第2期94-97,共4页
Chinese Journal of Clinical Gastroenterology
关键词
肝硬化
脑钠肽
食管胃底静脉曲张
内镜治疗
cirrhosis
brain natriuretic peptide
esophagogastric varices
endoscopic treatment
