摘要
目的探讨妊娠期糖尿病(GDM)对新生儿代谢水平及预后的影响。方法选取265例单胎GDM患者为观察组,260例健康单胎妊娠产妇作为对照组。测定血清脂联素、胰岛素、C肽、糖化血红蛋白和新生儿血糖水平等指标,比较两组新生儿的预后情况。结果观察组脐静脉脂联素水平及新生儿出生后2h血糖水平低于对照组,胰岛素、C肽及糖化血红蛋白水平均高于对照组,观察组剖宫产例数多于对照组,差异有统计学意义(P<0.05)。观察组低体质量儿、巨大儿、新生儿窒息、新生儿低血糖、新生儿高胆红素血症、新生儿肺炎、死胎、新生儿畸形发生率均明显高于对照组,差异具有统计学意义(P<0.05)。结论 GDM可引起新生儿代谢指标异常,影响胎儿生长发育,导致预后不良。
Objective Investigate the effect of gestational diabetes mellitus （GDM）on the neonatal metabolism and prognosis. Methods A total of 265 singleton pregnancy GDM patients were collected as the observation group,while 260 cases of healthy singleton pregnant women were chosen as the control group. Detected the levels of adiponectin, insulin, C-peptide, glycated hemoglobin and blood glucose, compared the prognosis of two groups. Results Compared with the control group,adiponcetin and blood glucose in 2 hours after birth in observation group were lower,insulin, C-peptide and glycated hemoglobin were higher, the number of cesarean section was more,the difference was statically significant （P〈0.05）. The incidence of low birth weight infant, macrosomia, neonatal asphyxia, neonatal hypoglycemia, neonatal hyperbilirubinemia, neonatal pneumonia, fetal death and newborn teratogenesis in the observation group was higher than that in the control group,the difference was statically significant （P〈0.05）. Conclusion GDM could cause metabolic disorder and affect fetal growth and development, leading to poor prognosis.
作者
邓毅
阳华妹
杨伟丽
唐正荣
雷凤
王丽
蒙真
谢勇
欧维琳
DENG Yi1 ,YANG Huamei1 ,YANG Weili1, TANG Zhengrong1 ,LEI Feng1 ,WANG Li1 , MENG Zhen1 ,XIE Yong1 ,OU Weilin2(1. Department of Neonatology ,the Second Affiliated Hospital of Guilin Medical College, Guilin, Guangxi 541199, China ; 2. the Affiliated Hospital of Guilin Medical College ,Guilin ,Guangxi 541199 ,Chin)
出处
《重庆医学》
CAS
2018年第13期1743-1745,共3页
Chongqing medicine
关键词
糖尿病
妊娠
脂联素
胰岛素
婴儿
新生
预后
diabetes, gestational
adiponcetin
insulin
infant, newborn
prognosis
