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替罗非班联合氯吡格雷治疗急性心肌梗死的临床疗效及对患者血清IL-6 TNF-α hs-CRP水平的影响 被引量:31

Clinical Effect of Tirofiban Combined with Clopidogrel on Acute Myocardial Infarction and the Levels of IL-6,TNF-α and hs-CRP in Serum
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摘要 目的:探讨替罗非班(TIR)结合氯吡格雷(CLO)治疗急性心肌梗死(AMI)的临床疗效及其对患者血清炎性细胞因子水平的影响。方法:选取我院2015年1月至2017年1月收治的AMI患者119例作为研究对象,通过简单随机法分为两组。观察组(60例)予以TIR结合CLO治疗,对照组(59例)仅予CLO治疗。比较两组的临床疗效,治疗前后血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)水平及不良反应的发生情况。结果:治疗后,观察组总有效率为95.0%,明显高于对照组(81.4%,P<0.05)。两组治疗后14d时,血清IL-6、TNF-α、hs-CRP均明显低于治疗前(P<0.01),且观察组血清IL-6、TNF-α、hs-CRP明显低于对照组(P<0.01)。两组治疗期间不良反应总发生率分别为6.7%、5.1%,比较无显著差异(P>0.05)。结论:替罗非班结合氯吡格雷治疗急性心肌梗死更能有效控制机体炎症反应,提高治疗效果,且安全性较高。 Objective: To explore the clinic effect of tirofiban( TIR) combined with clopidogrel( CLO)on acute myocardial infarction( AMI) and the levels of interleukin-6( IL-6),tumor necrosis factor-α( TNF-α) and high sensitivity C-reactive protein( hs-CRP) in serum. Methods: 119 cases of patients with AMI admitted in our hospital from January 2015 to January 2017 were selected as research objectives,and according to simple random method,those patients were divided into two groups. The observation group( 60 cases)was treated by TIR combined with CLO,while the control group( 59 cases) was treated by CLO. The clinical effect,changes of serum IL-6,TNF-α,hs-CRP levels before and after treatment as well as the incidence of adverse reactions were compared between two groups. Results: After treatment,the overall effective rate of observation group was 95.0%,which was significantly higher than that of the control group( 81.4%,P〈0.05).The serum IL-6,TNF-α,hs-CRP levels of both groups after treatment were significantly lower than those before treatment( P〈0.01),and the serum IL-6,TNF-α,hs-CRP of the observation group were significantly lower the in the control group at same time( P〈0.01). The total incidence of adverse reactions in the two groups was 6.7% and 5.1%,respectively,and there was no significant difference between the two groups.( P〉0.05). Conclusion: Tirofiban combined with clopidogrel could effectively control the inflammation and improve the treatment effect with high safety.
作者 张明 侯建伟 王西辉 梁蒙 吴娟 ZHANG Ming;HOU Jianwei;WANG Xihui(The Second Affiliated Hospital of Xi'an Medical University,Shaanxi Xi'an 710038,China)
出处 《河北医学》 CAS 2018年第5期763-766,共4页 Hebei Medicine
基金 陕西省自然科学基金项目 (编号:11JK167)
关键词 替罗非班 氯吡格雷 急性心肌梗死 炎性因子 Tirofiban Clopidogrel Acute myocardial infarction Inlammatory cytokine
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