摘要
目的探讨他克莫司滴眼液联合盐酸奥洛他定滴眼液治疗过敏性结膜炎的临床疗效。方法选取2015年1月—2016年12月四川大学华西医院眼科收治的过敏性结膜炎患者120例为研究对象,按随机数字法将所有患者分为对照组和治疗组,每组各60例。对照组给予盐酸奥洛他定滴眼液,1~2滴/次,3次/d。治疗组在对照组基础上给予他克莫司滴眼液,1滴/次,2次/d。两组患者均连续治疗1周。观察两组的临床疗效,比较两组的Schirmer试验、泪膜破裂时间(BUT)、角膜荧光素染色评分和症状体征改善时间。结果治疗后,对照组和治疗组的总有效率分别为81.67%、96.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组Schirmer试验、BUT明显升高,角膜荧光素染色评分、症状评分明显降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组结膜充血、眼痒、流泪改善时间均明显短于对照组,两组比较差异具有统计学意义(P<0.05)。结论他克莫司滴眼液联合盐酸奥洛他定滴眼液治疗过敏性结膜炎具有较好的临床疗效,可改善临床症状,缩短症状体征改善时间,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Tacrolimus Eye Drops combined with Olopatadine Hydrochloride Eye Drops in treatment of allergic conjunctivitis. Methods Patients（120 cases） with allergic conjunctivitis in Department of Ophthalmology of West China Hospital of Sichuan University from January 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were given Olopatadine Hydrochloride Eye Drops, 1 — 2 drops/time, three times daily. Patients in the treatment group were given Tacrolimus Eye Drops on the basis of the control group, 1 drop/time, twice daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacies were evaluated, and Schirmer test, BUT, corneal fluorescein staining score, and symptom improvement time in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.67% and 96.67%, respectively, and there was difference between two groups（P＜0.05）. After treatment, Schirmer test and BUT in two groups were significantly increased, but symptom score and corneal fluorescein staining score in two groups were significantly decreased, and the difference was statistically significant in the same group（P＜0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P＜0.05）. After treatment, the symptom improvement time of conjunctiva hyperemia, ophthalmic itching, and tears in the treatment group were significantly shorter than those in the control group, and there was difference between two groups（P＜0.05）. Conclusion Tacrolimus Eye Drops combined with Olopatadine Hydrochloride Eye Drops has clinical curative effect in treatment of allergic conjunctivitis, can improve clinical symptoms, and shorten symptom improvement time, which has a certain clinical application value.
作者
曾妮
ZENG Ni(Medical Examination Department of Ophthalmology, Health Management Center, West China Hospital of Sichuan University, Chengdu 610000, China)
出处
《现代药物与临床》
CAS
2018年第4期942-945,共4页
Drugs & Clinic
