摘要
目的：考察保妇康栓联合头孢曲松钠、甲硝唑治疗慢性盆腔炎的临床疗效。方法：选取2014年1月—2016年1月医院妇科门诊收治的患者126例,按随机数表法将患者随机分为实验组和对照组,对照组接受头孢曲松钠、甲硝唑治疗治疗,实验组接受保妇康栓联合头孢曲松钠、甲硝唑治疗。记录患者的临床症状、血液流变学、血清TNF-α、盆腔炎性包块大小和不良反应,统计和分析。结果：治疗后,实验组高切全血黏度、低切全血黏度、血浆黏度、红细胞比积和血沉均显著低于对照组（P〈0.05）;治疗后,实验组包块面积和TNF-α均显著低于对照组（P〈0.05）;实验组总有效率高于对照组（χ2=4.14,P〈0.05）;两组患者不良反应发生率无统计学差异（P〉0.05）;治疗后,实验组子宫及附件压痛、子宫活动差和附件增厚人数显著低于对照组（P〈0.01）。结论：保妇康栓联合头孢曲松钠、甲硝唑治疗慢性盆腔炎安全和有效,可显著改善患者的症状,增强患者免疫和改善血液流变学。
Objective： To evaluate the clinical efficacy and safety of Baofukang Suppository combined with ceftriaxone and metronidazole in the treatment of chronic pelvic inflammatory disease. Methods： We selected 126 cases of patients admitted in our hospital from January 2014 to January 2016. According to the random number table method,the patients were randomly divided into the experimental group and the control group. The control group received ceftriaxone sodium and metronidazole,and the experimental group received Baofukang Suppository combined with ceftriaxone sodium and metronidazole. The clinical symptoms,hemorheology,serum TNF-α,pelvic inflammatory mass and adverse reactions were recorded and analyzed. Results： After treatment,high blood viscosity,low shear whole blood viscosity,plasma viscosity,hematocrit and erythrocyte sedimentation rate of the experimental group were significantly lower than those of the control group（P〈0. 05）. After treatment,the edema area and TNF-α of the experimental group were significantly lower than those of the control group（P〈0. 05）. The total effective rate of the experimental group was higher than that of the control group（χ2= 4. 14,P〈0. 05）. There was no significant difference in the incidence of adverse reactions between two groups（P〉0. 05）. After treatment,the uterine and adnexal tenderness,uterine activity and the number of adnexal thickening in the experimental group were significantly lower than those in the control group（P〈0. 01）. Conclusions： Baofukang Suppository combined with ceftriaxone and metronidazole in the treatment of chronic pelvic inflammatory disease is safe and effective and can significantly improve the patients＇ symptoms,enhance immunity and improve blood rheology.
作者
陈进芳
刘玉珠
韩一栩
CHEN Jinfang1, LIU Yuzhu2, HAN Yixu2(1. Department of Pharmacy, The Second Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan, China; 2. Department of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan, Chin)
出处
《中华中医药学刊》
CAS
北大核心
2018年第5期1231-1233,共3页
Chinese Archives of Traditional Chinese Medicine
基金
海南省自然科学基金项目(813242)
关键词
保妇康栓
头孢曲松钠
甲硝唑
慢性盆腔炎
Baofukang Suppository
ceftriaxone sodium
metronidazole
chronic pelvic inflammatory disease
