摘要
目的探讨小剂量雌激素替代疗法与降压药物联合治疗围绝经期高血压患者对其血管内皮功能及血压的影响。方法选取该院收治的围绝经期高血压患者112例为研究对象,采用随机数字表法分为治疗组与对照组,对照组患者单纯给予降压药物治疗,治疗组患者给予小剂量雌激素替代疗法联合降压药物治疗,对2组患者治疗前后血压、性激素水平、血管内皮功能相关指标及Kupperman评分进行比较。结果治疗后,2组患者的舒张压与收缩压均较治疗前明显降低(P<0.05),但2组治疗后血压比较,差异无统计学意义(P>0.05);治疗后,治疗组患者的雌二醇(E2)明显较治疗前升高,且高于治疗后对照组,卵泡刺激素(FSH)、促黄体生成素(LH)水平明显较治疗前降低,且低于治疗后对照组,差异有统计学意义(P<0.05),对照组患者性激素水平治疗前后差异无统计学意义(P>0.05);治疗后,2组患者的内皮素-1(ET-1)、血管性血友病因子(VWF)均较治疗前降低,一氧化氮(NO)较治疗前升高(P<0.05),且治疗后治疗组患者的ET-1、VWF明显低于治疗后对照组,NO明显高于治疗后对照组(P<0.05);治疗后,治疗组患者的Kupperman评分明显较治疗前降低,且低于治疗后对照组(P<0.05),对照组患者的Kupperman评分治疗前后差异无统计学意义(P>0.05)。结论小剂量雌激素替代疗法与降压药物联合应用于围绝经期高血压患者的治疗可明显改善患者血管内皮功能及血压水平,并有助于改善围绝经期症状,值得临床推广。
Objective To investigate the effect of small dose of estrogen replacement therapy and antihypertensive therapy in elderly patients on vascular endothelial function and blood pressure in patients with perimenopause hypertension. Methods A total of 112 elderly patients with perimenopause hypertension were recruited as the research objects,and divided into treatment group and control group by random number table method,patients in the control group were treated with antihypertensive drug therapy,patients in the treatment group were given low-dose estrogen replacement therapy combined with drug treatment,the blood pressure,the levels of sex hormone and related indexes of vascular endothelial function and Kupperman score of two groups before and after treatment were compared. Results After treatment,systolic and diastolic blood pressure in the two groups were significantly lower than those before treatment （ P 〈0.05）,but the blood pressure of two groups had no statistically significant difference （ P 〉0.05）.After treatment,serum estradiol （E 2） of the patients in the treatment group was significantly higher than that before treatment,and higher than that in the control group after treatment,follicle-stimulating hormone（FSH） and luteinizing hormone （LH） after treatment significantly decreased,and lower than the control group after treatment （ P 〈0.05）,sex hormone levels in the control group before and after treatment had no significant change （ P 〉0.05）.After treatment,endothelin-1 （ET-1） and vascular hemophilia factor （VWF） in the two groups of patients were lower than those before treatment,nitric oxide （NO） increased than that before treatment （ P 〈0.05）,ET-1,VWF after treatment in the treatment group were significantly lower than those in the control group after treatment,NO was significantly higher than that in the control group after treatment （ P 〈0.05）.After treatment,Kupperman score in the treatment group decreased significantly after treatment,and
作者
孙莎
袁克芳
高志敏
武丽蕊
李红霞
SUN Sha;YUAN Kefang;GAO Zhimin;WU Lirui;LI Hongxia(Department of Obstetrics and Gynecology;Department of Cardiovascular Surgery,China NationalPetroleum Corporation Central Hospital,Langfang,Hebei 065000,China)
出处
《检验医学与临床》
CAS
2018年第9期1271-1273,1277,共4页
Laboratory Medicine and Clinic
关键词
围绝经期高血压
雌激素替代疗法
降压药物
血压
血管内皮功能
perimenopause hypertension
estrogen replacement therapy
antihypertensive drugs
blood pressure
vascular endothelial function
