摘要
氧化应激在肾间质纤维化发生发展中起着重要的作用,活性氧(ROS)是氧化应激过程中最重要的信号分子,烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶(NOX)途径生成的ROS是肾间质纤维化时ROS的主要来源,NOX4是NOX在肾脏的主要亚型,NOX1、NOX2、NOX5在肾脏中也有表达。NOX产生的ROS通过多种途径介导肾间质纤维化发生和进展。本文就NOX的不同亚型在肾间质纤维化中作用的研究进展做一综述。
Oxidative stress plays an important role in the development and progression of renal interstitial fibrosis. Reactive oxygen species（ ROS） are the most important signal molecules in the process of oxidative stress. ROS produced by the nicotinamide adenine dinucleotide phosphate（ NADPH） oxidase（ NOX） pathway is the major source of ROS during renal interstitial fibrosis. NOX4 is the major subtype of NOX in the kidney,and NOX1,NOX2,and NOX5 are also expressed in the kidney. The ROS produced by NOX mediates the development and progression of renal interstitial fibrosis through various pathways. This article reviewed the progress of research on roles of different subtypes of NOX in renal interstitial fibrosis.
作者
张丽
乔晞
Zhang Li, Qiao Xi(Department of Nephrology, Second Hospital of Shanxi Medical University, Shanxi Kidney Disease Institute, Taiyuan 030001, Shanxi Province, Chin)
出处
《中华肾病研究电子杂志》
2018年第1期44-46,共3页
Chinese Journal of Kidney Disease Investigation（Electronic Edition）
基金
山西省留学回国人员科技活动择优资助项目(2017-29)
山西省卫生计生委项目(201601043)
关键词
烟酰胺腺嘌呤二核苷酸磷酸氧化酶
肾间质纤维化
活性氧
Nicotinamide adenine dinucleotide phosphate oxidase
Renal interstitial fibrosis
Reactive oxygen species
