摘要
目的探讨硝苯地平缓释片与氨氯地平片单用或联合应用治疗糖尿病肾病合并高血压患者的疗效及相关血清学指标的影响。方法糖尿病肾病合并高血压患者90例,随机分为三组,每组30例。一组采用硝苯地平缓释片治疗,一组采用苯磺酸氨氯地平片治疗,一组两药联合应用。治疗前和治疗3个月后对血压、血肌酐、尿素、24 h尿蛋白、超敏C反应蛋白、血清膀胱抑素和同型半胱氨酸的水平进行检测。所获数据采用方差分析、t检验和2检验。结果三组治疗前血尿素、血肌酐、24 h尿蛋白、收缩压、舒张压相互比较,P均>0.05。硝苯地平组治疗前后血尿素、血肌酐水平变化比较,P<0.0005;24 h尿蛋白、收缩压水平变化比较,P均>0.05;舒张压水平变化比较,P<0.005。氨氯地平组治疗前后血尿素、血肌酐水平变化比较,P均<0.0005;24 h尿蛋白水平变化比较,P<0.05;收缩压水平变化比较,P>0.05;舒张压水平变化比较,P<0.005。联合组治疗前后血尿素、血肌酐、24 h尿蛋白、收缩压、舒张压水平变化比较,P均<0.0005。硝苯地平组与氨氯地平组治疗后血尿素、24 h尿蛋白、收缩压、舒张压水平变化比较,P均>0.05;血肌酐水平变化比较,P<0.05。硝苯地平组与联合组治疗后血尿素、24 h尿蛋白、收缩压、舒张压水平变化比较,P均<0.0005;血肌酐水平变化比较,P<0.005。氨氯地平组与联合组治疗后血尿素、血肌酐、24 h尿蛋白、收缩压、舒张压水平变化比较,P均<0.0005。硝苯地平组与氨氯地平组治疗前超敏C反应蛋白、血清膀胱抑素、同型半胱氨酸水平比较,P均>0.05。硝苯地平组与联合组治疗前超敏C反应蛋白、血清膀胱抑素、同型半胱氨酸水平比较,P均>0.05。氨氯地平组与联合组治疗前超敏C反应蛋白、血清膀胱抑素、同型半胱氨酸水平比较,P均>0.05。硝苯地平组治疗前后超敏C反应蛋白、血清膀胱抑素、同型半胱氨酸�
Objective To explore the effect of nifedipine sustained release tablets, amlodipine tablets and their combi- nation on the efficacy and serological indexes of diabetic nephropathy patients with hypertension. Methods 90 patients with diabetic nephropathy and hypertension were randomly divided into three groups, 30 cases in each group. One group was treated with nifedipine sustained-release tablets, one group with amlodipine besylate tablets and one group with the combination of two drugs. Blood pressure, serum creatinine, urea, 24 h urine protein, high-sensitivity C-reactive protein（hs-CRP）, serum cystatin（Cys） and homocysteine（Hcy） were measured before treatment and 3 months after treatment. The data were analyzed by variance analysis, t test and χ^2 test. Results Blood urea, serum creatinine, 24 h urine protein, systolic blood pressure and diastolic blood pressure were compared among the three groups before treatment with all P〉0.05. The changes of serum urea and serum creatinine in nifedipine group before and after treatment were compared with P〈0.0005; Comparison of 24 h urinary protein and systolic blood pressure were P〉0.05; Comparison of diastolic blood pressure was P〈0.005. The changes of serum urea and serum creatinine in amlodipine group before and after treatment were compared with P〈0.0005; Comparison of 24 h urinary protein level was P〈0.05; Comparison of systolic blood pressure was P〉0.05; Comparison of diastolic blood pressure was P〈0.005. The changes of the above indexes in the combined group before and after treatment were compared with P〈0.0005. The changes of serum urea, 24 h urine protein, systolic pressure and diastolic pressure were compared between nifedipine group and amlodipine group after treatment with P〉0.05; The serum creatinine levels were compared with P〈0.05. The changes of serum urea, 24 h urine protein, systolic blood pressure and diastolic blood pressure were compared between nifedipine group and combination group after treatment with P〈0.0005
作者
黄海齐
Huang Haiqi(Heze Hospital of Traditional Chinese Medicine, Heze 274000, Shandon)
出处
《菏泽医学专科学校学报》
2018年第1期28-31,51,共5页
Journal of Heze Medical College
