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瑞巴派特治疗幽门螺杆菌阴性胃溃疡细胞因子变化和疗效分析 被引量:12

Change of cytokines in patients with helicobacter pylori negative gastric ulcers after treatment of rebamipide
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摘要 目的:研究瑞巴派特在治疗幽门螺杆菌(helicobacter pylori,Hp)阴性胃溃疡的效果,并观察治疗后细胞因子变化。方法:选取经胃镜检查及13C尿素呼气试验明确为Hp阴性的胃溃疡患者90例,随机分为质子泵抑制剂(proton-pump inhibitor,PPI)组、铋剂+PPI组和瑞巴派特+PPI组3组,PPI组给予泮托拉唑,铋剂+PPI组给予铋剂和泮托拉唑,瑞巴派特+PPI组给予瑞巴派特和泮托拉唑治疗,疗程4周,观察治疗后溃疡愈合情况及细胞因子变化情况。结果:瑞巴派特+PPI组比PPI组治疗效果更好,瑞巴派特+PPI组IL-1,IL-6和MDA和其他两组比较均明显降低,而EGF,PGE_2,NO以及VEGF均明显升高,差异具有统计学意义(P<0.05)。结论:瑞巴派特在治疗Hp阴性的胃溃疡有良好的效果,可以降低侵袭因子,增加保护因子的合成。 Objective:To analyze the therapeutic effect of rebamipide for helicobacter pylori(Hp) negative gastric ulcers,and observe the change of cytokines after treatment.Methods:Ninety Hp negative gastric ulcer patients were chosen,who were diagnosed by endoscopy and13 C urea breath test,and divided into PPI group,bismuth + PPI group and rebamipide + PPI group randomly.The three groups received pantoprazole alone,pantoprazole plus bismuth and rebamipide plus pantoprazole separately for 4 weeks.The effect of the treatment and the levels of cytokines after the treatment were compared among the three groups.Results:The rebamipide + PPI group achieved a better effect than the PPI group.And the levels of IL-1,IL-6,and MDA of the rebamipide + PPI group were significantly lower than those of the other two groups,while the levels of EGF,PGE_2,NO and VEGF were significantly higher(P〈0.05).Conclusion:Rebamipide is effective for the treatment of Hp negative gastric ulcers.And rebamipide can reduce the levels of aggressive factors and increase the systhesis of protective factors.
作者 刘新尧 王晓辉 王少鑫 闫志辉 罗哲 崔立红 LIU Xin-yao;WANG Xiao-hui;WANG Shao-xin;YAN Zhi-hui;LUO Zhe;CUI Li-hong(Department of Gastroenterology, Navy General Hospital, Beijing 100048, China)
出处 《中国新药杂志》 CAS CSCD 北大核心 2018年第8期910-913,共4页 Chinese Journal of New Drugs
基金 吴阶平医学基金会临床科研专项基金资助项目(320.6750.16022)
关键词 胃溃疡 细胞因子 瑞巴派特 gastric ulcer cytokine rebamipide
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