摘要
目的:采用Box-Behnken响应面法对小承气汤煎煮条件进行优化。方法:以大黄酸、芦荟大黄素和辛弗林为评价指标,进行了药液比、煎煮次数、煎煮时间三因素的单因素考察;以指标性成分提取率的加权计算结果为指标,采用Box-Behnken响应面法优化上述三个因素。结果:最佳条件为药液比1∶10、煎煮次数3次、煎煮时间1.0 h,实测值与预测值偏差为1.15%。结论:最佳煎煮工艺提取效果良好,结果可靠。
Objective： To optimize the decoction process of Xiaochengqi decoction by Box-Behnken response surface method. Methods： Rhein, aloe-emodin and synephrine were chosen as the evaluation indices. After the material-liquid ratio, decocting frequency and decocting time were studied, Box-Behnken response surface method was used to optimize the three factors using the weighted calculation value of the extraction rate of above indicator components. Results ： The best conditions were as follows ： the material-liquid ratio was 1：10, the decocting frequency was 3, and the decocting time was 1.0 h. The deviation of measured value and predicted value was 1.15%. Conclusion： The best decocting conditions are promising and reliable.
作者
施理画
Shi Lihua(Jiashan First People＇s Hospital, Zhejiang Jiaxing 314100, China)
出处
《中国药师》
CAS
2018年第5期813-817,共5页
China Pharmacist
