摘要
目的:探讨优甲乐在治疗妊娠期妇女亚临床甲状腺功能减退患者妊娠结局的影响。方法:纳入2016年3月至2018年3月在南昌市第一医院就诊孕早期亚临床甲状腺功能减退患者53例,正常孕早期孕妇53例,随机分为两组。优甲乐组给予起始剂量为25~50μg/m L优甲乐进行治疗,对照组给予同等剂量安慰剂。记录患者血清促甲状腺激素(TSH)达标时间和用药剂量。结果:与完全对照组相比,优甲乐组TSH降至正常值所用时间为(3.15±0.72)周,优甲乐的剂量为(50.05±7.25)μg/m L。妊娠期间高血压、糖尿病、贫血等并发症无显著性差异,新生儿流产、早产率、畸形率无显著性差异。结论:优甲乐能有效地治疗妊娠期甲减妇女,并在(3.15±0.72)周给药(50.05±7.25)μg/m L达到治疗效果。
Objective： To investigate the effect of levothyroxine sodium tablets（Euthyrox） in the treatment of pregnant women with subclinical hypothyroidism. Methods： A total of 53 patients with subclinical hypothyroidism in early pregnancy from March 2016 to March 2018 and 53 healthy pregnant women were enrolled in the First Hospital of Nanchang City and were divided into two groups.The treatment group received a starting dose of 25-50 μg/mL Euthyrox for treatment, while the control group received the same dose of placebo. Patient＇s serum thyroid stimulating hormone（TSH）, onset time, therapeutic dose and pregnancy outcomes were analyzed between two groups. Results： Compared with the control group, the onset time in the Euthyrox group was（3.15±0.72） week, and the therapeutic dose was （50.05±7.25） μg/mL. There was no signi？cant difference in the occurrence rate of hypertension, diabetes, and anemia during pregnancy. There was no signi？cant difference in the occurrence rate of neonatal abortion, preterm delivery and malformation. Conclusion： Euthyrox can effectively treat women with hypothyroidism during pregnancy and achieve therapeutic effect at（3.15±0.72） week on （50.05±7.25） μg/mL.
作者
万静雯
何志连
邓雯
WAN Jing-wen;HE Zhi-lian;DENG Wen(The First Hospital of Nanchang City, Nanchang Jiangxi 330008, Chin)
出处
《药品评价》
CAS
2018年第9期13-16,共4页
Drug Evaluation
基金
南昌市指导性科技计划项目(项目立项文号:洪科发计字[2016]96号
项目编号:第32项)
