摘要
目的探讨心肺联合超声对重度左心衰竭伴肺动脉高压患者的临床意义。方法选择2016年3月至2017年6月青岛大学医学院附属青岛市市立医院收治的Ⅲ、Ⅳ级左心衰竭伴呼吸困难患者75例。其中33例患者肺动脉压力正常(肺动脉压力正常组),25例患者轻度肺动脉高压(轻度肺动脉高压组),17例患者中重度肺动脉高压(中重度肺动脉高压组)。检测患者血浆B型钠利尿肽(BNP),超声心动图测量患者左心室内径(LVD)、右心室内径(RVD)、左心室射血分数(LVEF),肺部超声检查观察患者肺部B线并记录其数量。采用单因素方差分析比较3组重度左心衰竭患者LVD、RVD、LVEF差异,进一步组间两两比较采用LSD-t检验;采用Kruskal-wallis H检验比较3组重度左心衰竭患者血浆BNP浓度、B线数目,进一步组间两两比较采用Mann-Whitney U检验。绘制血浆BNP浓度、B线数目诊断重度左心衰竭患者肺动脉高压的受试者工作特征(ROC)曲线。结果肺动脉压力正常组、轻度肺动脉高压组、中重度肺动脉高压组重度左心衰竭患者血浆BNP浓度分别为890(614,1516)、1460(1245,1950)、2660(1670,3279)ng/L,B线数目分别为12(9,16)、17(14,18)、26(20,28)条,RVD分别为(22.1±1.7)、(24.9±2.0)、(26.3±2.8)mm,血浆BNP浓度、B线数目、RVD均为中重度肺动脉高压组>轻度肺动脉高压组>肺动脉压力正常组,且任意两组间比较差异均有统计学意义(血浆BNP浓度:U=210.500,P<0.05;U=47.000、73.000,P均<0.001;B线数目:U=189.000,P<0.05;U=38.5000、64.000,P均<0.001;RVD:t=0.553、0.623,P均<0.001;t=0.656,P<0.05)。而3组重度左心衰竭患者LVD、LVEF差异均无统计学意义。ROC曲线显示,血浆BNP浓度诊断重度左心衰竭患者肺动脉高压的最佳阈值为1225 ng/L,敏感度为85.7%,特异度为69.7%,曲线下面积为0.814,95%CI为0.717~0.911;B线数目诊断重度左心衰竭患者肺动脉高压的最佳阈值为14条,敏感度为88.1%,特异度为66.7%,曲线下面积
Objective To investigate the clinical significance of combined heart and lung ultrasound in patients with severe left heart failure and pulmonary hypertension. Methods From March 2016 to June 2017, 75 patients with grade Ⅲ and Ⅳ heart failure and dyspnea were enrolled in Qingdao Municipal Hospital Affiliated to Qingdao University. Thirty-three patients had normal pulmonary artery pressure（normal pulmonary arterial pressure group）, 25 patients had mild pulmonary hypertension（mild pulmonary hypertension group）, and 17 patients had moderate to severe pulmonary hypertension（moderate to severe pulmonary hypertension group）. The patient′s plasma B-type natriuretic peptide（BNP） was measured. Left ventricular diameter（LVD）, right ventricular diameter（RVD）, and left ventricular ejection fraction（LVEF） were measured by echocardiography. The patient′s lungs were observed by lung ultrasonography, and its number was recorded. One-way analysis of variance was used to compare the differences of LVD, RVD, and LVEF in three groups of patients with severe left heart failure. Further comparison between groups was performed using LSD-t test. Kruskal-wallis H test was used to compare the plasma BNP concentration and B-line number in three groups of patients with severe left heart failure. The Mann-Whitney U test was used to further compare the groups. The receiver operating characteristic（ROC） curve of pulmonary hypertension diagnosed by plasma BNP concentration and B line number in patients with severe left heart failure were drwan. Results The concentrations of BNP in patients with normal pulmonary arterial pressure, mild pulmonary hypertension, and moderate to severe pulmonary hypertension were 890（614, 1516）, 1460（1245, 1950）, and 2660（1670, 3279） ng/L, respectively. The number of B line was 12（9, 16）, 17（14, 18）, 26（20, 28）, and the RVD was（22.1±1.7）,（24.9±2.0）,（26.3±2.8） mm, respectively. The number of B-line and RVD in the moderate-severe pulmonary
作者
刘刚
韩彤亮
杜丽珍
李睿
类婷婷
唐国璋
张司敏
马西顺
Liu Gang;Han Tongliang;Du Lizhen;Li Rui;Lei Tingting;Tang Guozhang;Zhang Simin;Ma Xishun(Department of Ultrasound, 2Department of Cardiac Ultrasound, Qingdao Municipal Hospital of Qingdao University, Qingdao 266071, China)
出处
《中华医学超声杂志（电子版）》
CSCD
2017年第12期927-932,共6页
Chinese Journal of Medical Ultrasound(Electronic Edition)
基金
青岛市卫生科技计划项目(2015-WJZD004)
关键词
超声检查
心力衰竭
高血压
肺性
Ultzasonography
Heart failure
Hypertension, pulmonary
