摘要
目的探讨胸苷激酶1（thymidinekinase1，TK1）在良恶性乳腺肿瘤中的表达及意义。方法选取2013年5月至2015年5月青岛大学医学院第二附属医院乳腺医学中心收治的16—79岁女性乳腺疾病180例，其中乳腺癌112例（乳腺癌组），乳腺纤维腺瘤68例（乳腺纤维腺瘤组）。患者平均年龄47岁，中位年龄43岁。所有对象均采集空腹静脉血，检测TK1水平，并比较其在纤维腺瘤及乳腺癌患者中表达水平的差异，及血清TK1水平在不同病理特征的患者中的差异。结果乳腺癌患者的TK1水平明显高于纤维腺瘤患者的TK1水平，差异有统计学意义（P〈0．01）。在乳腺癌组中，肿块的大小与TK1的表达无关（P〉0．05）；TNM分期较晚的患者血清TK1水平高于TNM分期早期的患者，差异有统计学意义（P=0．038）；淋巴结分期晚期的患者血清TK1水平高于分期早期患者，差异有统计学意义（P=0．048）。M1的患者TK1水平高于M0的患者，差异有统计学意义（p=0．018）。结论TK1作为一种新型细胞增殖指数标志物，可较为准确地反映人体内肿瘤细胞的增殖水平，可作为一种监测肿瘤增殖程度和鉴别肿瘤良恶性的重要参考指标。
Objective To investigate the expression of thymidine kinase 1 （TK1） in benign and malignant tumors. Methods From Jan. 2013 to May. 2015, 180 female patients with breast diseases aging 16 to 79 years, including 112 cases of breast cancer （breast cancer group）, and 68 cases of breast fibroadenoma （breast fibroade- noma group） were collected. The mean age of the patients was 47 years, with a median age of 43 years. We col- lected all the patients＇ fasting venous blood, detected the level of TK1, compared their differences of expression levels between patients with fibroadenoma and breast cancer, and the differences in serum TK1 levels in patients with different pathological characteristics. Results The level of TK1 in breast cancer patients was significantly higher than that in patients with fibroadenoma, and the difference was statistically significant （P〈0.01）. In breast cancer group, the tumor size was not correlated with TK1 expression of （P〉0.05）. The level of serum TK1 in pa- tients with advanced TNM stage was higher than that in patients with early TNM stage （P=0.038）. The level of serum TK1 in patients with advanced lymph node stage was higher than that in early lymph node stage （P=0.048）. The level of TK1 in M1 patients was higher than that in M0 patients and the difference had statistical signifi- cance （P=-0.018）. Conclusion TK1, as a new marker of cell proliferation index, can accurately reflect the pro- liferation of tumor ceils in human body, which can be used as an important index to monitor the degree of tumor proliferation and identify benign and malignant tumors.
出处
《中华内分泌外科杂志》
CAS
2017年第5期377-379,共3页
Chinese Journal of Endocrine Surgery
基金
2015山东省医务职工科技创新计划（2015wszd065）
